登録情報 | データベース: PDB / ID: 8g4z |
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タイトル | E. coli DHFR complex with NADP+ and folate: EF-X off model by Laue diffraction (no electric field) |
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要素 | Dihydrofolate reductase |
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キーワード | OXIDOREDUCTASE / Dihydrofolate Reductase |
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機能・相同性 | 機能・相同性情報
methotrexate binding / dihydrofolic acid binding / response to methotrexate / NADP+ binding / folic acid binding / dihydrofolate metabolic process / glycine biosynthetic process / dihydrofolate reductase / dihydrofolate reductase activity / folic acid metabolic process ...methotrexate binding / dihydrofolic acid binding / response to methotrexate / NADP+ binding / folic acid binding / dihydrofolate metabolic process / glycine biosynthetic process / dihydrofolate reductase / dihydrofolate reductase activity / folic acid metabolic process / NADPH binding / tetrahydrofolate biosynthetic process / one-carbon metabolic process / NADP binding / response to xenobiotic stimulus / response to antibiotic / cytosol類似検索 - 分子機能 Dihydrofolate reductase / Dihydrofolate reductase conserved site / Dihydrofolate reductase (DHFR) domain signature. / Dihydrofolate reductase domain / Dihydrofolate reductase / Dihydrofolate reductase (DHFR) domain profile. / Dihydrofolate reductase-like domain superfamily類似検索 - ドメイン・相同性 FOLIC ACID / : / NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE / Dihydrofolate reductase類似検索 - 構成要素 |
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生物種 | ![](img/tx_bacteria.gif) Escherichia coli (大腸菌) |
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手法 | X線回折 / シンクロトロン / フーリエ合成 / 解像度: 1.7 Å |
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データ登録者 | Greisman, J.B. / Dalton, K.M. / Brookner, D.E. / Klureza, M.A. / Hekstra, D.R. |
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資金援助 | 米国, 4件 組織 | 認可番号 | 国 |
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Searle Scholars Program | SSP-2018-3240 | | George W. Merck Fund in the New York Community Trust | 338034 | | National Institutes of Health/Office of the Director | DP2-GM141000 | 米国 | National Science Foundation (NSF, United States) | DGE1745303 | 米国 |
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引用 | ジャーナル: To Be Published タイトル: E. coli DHFR complex with NADP+ and folate: EF-X off model by Laue diffraction (no electric field) 著者: Greisman, J.B. / Dalton, K.M. / Brookner, D.E. / Klureza, M.A. / Hekstra, D.R. |
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履歴 | 登録 | 2023年2月10日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2024年1月3日 | Provider: repository / タイプ: Initial release |
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