- PDB-8fp3: PKCeta kinase domain in complex with compound 11 -
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基本情報
登録情報
データベース: PDB / ID: 8fp3
タイトル
PKCeta kinase domain in complex with compound 11
要素
Protein kinase C eta type
キーワード
TRANSFERASE/INHIBITOR / HPK1 / Structure based drug design / cancer / kinase / TRANSFERASE / TRANSFERASE-INHIBITOR complex
機能・相同性
機能・相同性情報
diacylglycerol-dependent, calcium-independent serine/threonine kinase activity / positive regulation of B cell receptor signaling pathway / protein kinase C signaling / protein kinase C / negative regulation of glial cell apoptotic process / diacylglycerol-dependent serine/threonine kinase activity / Effects of PIP2 hydrolysis / positive regulation of macrophage derived foam cell differentiation / positive regulation of keratinocyte differentiation / regulation of bicellular tight junction assembly ...diacylglycerol-dependent, calcium-independent serine/threonine kinase activity / positive regulation of B cell receptor signaling pathway / protein kinase C signaling / protein kinase C / negative regulation of glial cell apoptotic process / diacylglycerol-dependent serine/threonine kinase activity / Effects of PIP2 hydrolysis / positive regulation of macrophage derived foam cell differentiation / positive regulation of keratinocyte differentiation / regulation of bicellular tight junction assembly / positive regulation of glial cell proliferation / positive regulation of protein localization to plasma membrane / small GTPase binding / G alpha (z) signalling events / cell-cell junction / positive regulation of NF-kappaB transcription factor activity / cell differentiation / protein kinase activity / intracellular signal transduction / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / enzyme binding / signal transduction / extracellular exosome / ATP binding / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能
Protein kinase C, eta / Novel protein kinase C eta, catalytic domain / Protein kinase C, delta/epsilon/eta/theta types / Protein kinase, C-terminal / Protein kinase C terminal domain / Diacylglycerol/phorbol-ester binding / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / C2 domain / Protein kinase C conserved region 2 (CalB) ...Protein kinase C, eta / Novel protein kinase C eta, catalytic domain / Protein kinase C, delta/epsilon/eta/theta types / Protein kinase, C-terminal / Protein kinase C terminal domain / Diacylglycerol/phorbol-ester binding / Phorbol esters/diacylglycerol binding domain (C1 domain) / Zinc finger phorbol-ester/DAG-type signature. / C2 domain / Protein kinase C conserved region 2 (CalB) / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C2 domain / C2 domain profile. / C1-like domain superfamily / Extension to Ser/Thr-type protein kinases / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / C2 domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性
温度: 286.15 K / 手法: 蒸気拡散法, シッティングドロップ法 / pH: 6 詳細: Well Ingredients: Precipitant: 21.0 %w/v (10.5 uL of stock 50.0 %w/v) PEG 3350 Salt: 0.7 M (2.1875 uL of stock 8.0 M) lithium nitrate Buffer: 0.1 M (2.5 uL of stock 1.0 M) MES (pH 6.00) ...詳細: Well Ingredients: Precipitant: 21.0 %w/v (10.5 uL of stock 50.0 %w/v) PEG 3350 Salt: 0.7 M (2.1875 uL of stock 8.0 M) lithium nitrate Buffer: 0.1 M (2.5 uL of stock 1.0 M) MES (pH 6.00) Organic (non-volatile): 7.0 % w/v (2.1875 uL of stock 80.0 % w/v) Glycerol [Protien] = 12 mg/ml Temp details: 13 degrees C.