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- PDB-8fmh: Structure of CBASS Cap5 from Pseudomonas syringae as an activated... -

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基本情報

登録情報
データベース: PDB / ID: 8fmh
タイトルStructure of CBASS Cap5 from Pseudomonas syringae as an activated tetramer with the cyclic dinucleotide 3'2'-c-dGAMP ligand (2 tetramers in the AU)
要素SAVED domain-containing protein
キーワードIMMUNE SYSTEM / cyclic dinucleotide / bacterial immunity / CBASS / Cap5 effector DNA endonuclease / viral defense
機能・相同性HNH endonuclease / SMODS-associated and fused to various effectors / SMODS-associated and fused to various effectors sensor domain / HNH nuclease / 3'2'-cGAMP / DI(HYDROXYETHYL)ETHER / TRIETHYLENE GLYCOL / HNH endonuclease
機能・相同性情報
生物種Pseudomonas syringae (バクテリア)
手法X線回折 / シンクロトロン / 分子置換 / 解像度: 1.87 Å
データ登録者Rechkoblit, O. / Kreitler, D.F. / Aggarwal, A.K.
資金援助 米国, 1件
組織認可番号国
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)GM13170 米国
引用ジャーナル: Nat.Struct.Mol.Biol. / 年: 2024
タイトル: Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides.
著者: Rechkoblit, O. / Sciaky, D. / Kreitler, D.F. / Buku, A. / Kottur, J. / Aggarwal, A.K.
履歴
登録2022年12月23日登録サイト: RCSB / 処理サイト: RCSB
改定 1.02024年2月7日Provider: repository / タイプ: Initial release
改定 1.12024年2月21日Group: Database references / カテゴリ: citation / Item: _citation.pdbx_database_id_PubMed / _citation.title
改定 1.22024年5月29日Group: Database references / カテゴリ: citation / citation_author
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID

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構造の表示

構造ビューア分子:
MolmilJmol/JSmol

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集合体

登録構造単位
A: SAVED domain-containing protein
B: SAVED domain-containing protein
C: SAVED domain-containing protein
D: SAVED domain-containing protein
E: SAVED domain-containing protein
F: SAVED domain-containing protein
G: SAVED domain-containing protein
H: SAVED domain-containing protein
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)348,66437
ポリマ－342,1548
非ポリマー6,51029
水17,583976
1
A: SAVED domain-containing protein
B: SAVED domain-containing protein
C: SAVED domain-containing protein
D: SAVED domain-containing protein
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)174,30818
ポリマ－171,0774
非ポリマー3,23114
水724
タイプ名称対称操作数
identity operation1_555x,y,z1
Buried area18760 Å2
ΔGint-95 kcal/mol
Surface area53290 Å2
手法PISA
2
E: SAVED domain-containing protein
F: SAVED domain-containing protein
G: SAVED domain-containing protein
H: SAVED domain-containing protein
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)174,35619
ポリマ－171,0774
非ポリマー3,27915
水724
タイプ名称対称操作数
identity operation1_555x,y,z1
Buried area19780 Å2
ΔGint-88 kcal/mol
Surface area52560 Å2
手法PISA
単位格子
Length a, b, c (Å)67.970, 295.678, 84.052
Angle α, β, γ (deg.)90.000, 113.790, 90.000
Int Tables number4
Space group name H-MP1211
Space group name HallP2yb
Symmetry operation#1: x,y,z
#2: -x,y+1/2,-z

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要素

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タンパク質 , 1種, 8分子 ABCDEFGH

#1: タンパク質
SAVED domain-containing protein / CBASS Cap5


分子量: 42769.238 Da / 分子数: 8 / 由来タイプ: 組換発現
由来: (組換発現) Pseudomonas syringae (バクテリア)
発現宿主: Escherichia coli (大腸菌) / 参照: UniProt: A0A2P0QGK5

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非ポリマー , 7種, 1005分子

#2: 化合物
ChemComp-4UR / 3'2'-cGAMP / 2-amino-9-[(2S,5R,7R,8R,10R,12aR,14R,15R,15aS,16R)-7-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxy-2,10-dioxidooctahydro-12H-5,8-methanofuro[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecin-14-yl]-1,9-dihydro-6H-purin-6-one


分子量: 674.411 Da / 分子数: 8 / 由来タイプ: 合成 / 式: C20H24N10O13P2 / タイプ: SUBJECT OF INVESTIGATION
#3: 化合物
ChemComp-ZN / ZINC ION


分子量: 65.409 Da / 分子数: 8 / 由来タイプ: 合成 / 式: Zn
#4: 化合物
ChemComp-MG / MAGNESIUM ION / マグネシウムジカチオン


分子量: 24.305 Da / 分子数: 10 / 由来タイプ: 合成 / 式: Mg
#5: 化合物 ChemComp-PGE / TRIETHYLENE GLYCOL / トリエチレングリコ-ル


分子量: 150.173 Da / 分子数: 1 / 由来タイプ: 合成 / 式: C6H14O4
#6: 化合物 ChemComp-PEG / DI(HYDROXYETHYL)ETHER / ジエチレングリコ-ル


分子量: 106.120 Da / 分子数: 1 / 由来タイプ: 合成 / 式: C4H10O3
#7: 化合物 ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL / グリセロ-ル


分子量: 92.094 Da / 分子数: 1 / 由来タイプ: 合成 / 式: C3H8O3
#8: 水 ChemComp-HOH / water


分子量: 18.015 Da / 分子数: 976 / 由来タイプ: 天然 / 式: H2O

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詳細

研究の焦点であるリガンドがあるかY

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実験情報

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実験

実験手法: X線回折 / 使用した結晶の数: 1

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試料調製

結晶マシュー密度: 2.26 Å3/Da / 溶媒含有率: 45.55 %
結晶化温度: 293 K / 手法: 蒸気拡散法, ハンギングドロップ法
詳細: 0.1 M Bis-Tris, pH 5.5-6.0, 0.2 M magnesium chloride, 19-20% PEG3350
PH範囲: 5.5-6.0

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データ収集

回折平均測定温度: 100 K / Serial crystal experiment: N
放射光源由来: シンクロトロン / サイト: NSLS-II / ビームライン: 17-ID-1 / 波長: 0.920105 Å
検出器タイプ: DECTRIS EIGER2 S 9M / 検出器: PIXEL / 日付: 2022年3月21日
放射プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray
放射波長波長: 0.920105 Å / 相対比: 1
反射解像度: 1.87→147.839 Å / Num. obs: 151543 / % possible obs: 93.6 % / 冗長度: 4 % / Biso Wilson estimate: 29.27 Å2 / CC1/2: 0.994 / Rmerge(I) obs: 0.125 / Net I/σ(I): 6.9
反射 シェル解像度: 1.871→2.112 Å / Rmerge(I) obs: 0.753 / Num. unique obs: 7577 / CC1/2: 0.644

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解析

ソフトウェア
名称バージョン分類
PHENIX1.20.1_4487精密化
PHENIX1.20.1_4487精密化
XDSデータ削減
Aimlessデータスケーリング
PHASER位相決定
精密化構造決定の手法: 分子置換
開始モデル: PDB entry 8FMF

8fmf


解像度: 1.87→38.45 Å / SU ML: 0.2671 / 交差検証法: FREE R-VALUE / σ(F): 1.36 / 位相誤差: 34.0032
立体化学のターゲット値: GeoStd + Monomer Library + CDL v1.2
Rfactor反射数%反射
Rfree0.2533 7516 4.96 %
Rwork0.2098 143973 -
obs0.212 151489 61.05 %
溶媒の処理減衰半径: 0.9 Å / VDWプローブ半径: 1.1 Å / 溶媒モデル: FLAT BULK SOLVENT MODEL
原子変位パラメータBiso mean: 53.54 Å2
精密化ステップサイクル: LAST / 解像度: 1.87→38.45 Å
タンパク質核酸リガンド溶媒全体
原子数22017 0 401 976 23394
拘束条件
Refine-IDタイプDev ideal数
X-RAY DIFFRACTIONf_bond_d0.003222977
X-RAY DIFFRACTIONf_angle_d0.614731444
X-RAY DIFFRACTIONf_chiral_restr0.04193554
X-RAY DIFFRACTIONf_plane_restr0.00554136
X-RAY DIFFRACTIONf_dihedral_angle_d14.42688554
LS精密化 シェル
解像度 (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
1.87-1.890.214880.2818190X-RAY DIFFRACTION2.41
1.89-1.910.2485100.2907279X-RAY DIFFRACTION3.52
1.91-1.940.39150.3128346X-RAY DIFFRACTION4.39
1.94-1.960.3877190.3189437X-RAY DIFFRACTION5.53
1.96-1.990.2517360.2841635X-RAY DIFFRACTION8.16
1.99-2.020.3366250.3019895X-RAY DIFFRACTION11.19
2.02-2.040.3566530.29051152X-RAY DIFFRACTION14.48
2.04-2.080.3257850.29551356X-RAY DIFFRACTION17.57
2.08-2.110.3141870.29311679X-RAY DIFFRACTION21.3
2.11-2.140.253900.28121976X-RAY DIFFRACTION25.12
2.14-2.180.30791550.27792423X-RAY DIFFRACTION31.29
2.18-2.220.32171450.27573108X-RAY DIFFRACTION39.24
2.22-2.260.29751970.27114039X-RAY DIFFRACTION51.12
2.26-2.310.30672760.27585006X-RAY DIFFRACTION64.69
2.31-2.360.32352860.26265789X-RAY DIFFRACTION73.07
2.36-2.410.29663140.26746343X-RAY DIFFRACTION80.04
2.41-2.470.33673620.26846707X-RAY DIFFRACTION85.8
2.47-2.540.3083870.25757425X-RAY DIFFRACTION94.3
2.54-2.610.30463910.26037820X-RAY DIFFRACTION99.07
2.61-2.70.29084010.24837840X-RAY DIFFRACTION99.96
2.7-2.80.29474680.25147801X-RAY DIFFRACTION99.99
2.8-2.910.28323890.24247899X-RAY DIFFRACTION99.96
2.91-3.040.27384290.22217789X-RAY DIFFRACTION99.79
3.04-3.20.24213930.21417866X-RAY DIFFRACTION99.81
3.2-3.40.26373710.20247940X-RAY DIFFRACTION99.88
3.4-3.660.23954190.19087869X-RAY DIFFRACTION99.82
3.66-4.030.21634380.1697794X-RAY DIFFRACTION99.55
4.03-4.610.20744380.14927786X-RAY DIFFRACTION99.72
4.61-5.810.20933810.17027925X-RAY DIFFRACTION99.87
5.81-38.450.23134480.20367859X-RAY DIFFRACTION99.37
精密化 TLS手法: refined / Origin x: 16.928 Å / Origin y: 102.926 Å / Origin z: 17.449 Å
111213212223313233
T0.142835807555 Å20.0810613797245 Å20.00651310129596 Å2-0.235453818678 Å20.00515011844351 Å2--0.140024499368 Å2
L0.172319477197 °2-0.136568907731 °20.0559777518991 °2-0.911319807167 °20.0315996816898 °2--0.285770012244 °2
S-0.034392772543 Å °-0.0274169268225 Å °0.0241295245414 Å °0.228950734018 Å °0.0342213745307 Å °-0.171237867691 Å °-0.00765679729233 Å °-0.0602195022992 Å °0.002121977337 Å °
精密化 TLSグループ
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )A14 - 382
2X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )A401
3X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )A402
4X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )A403 - 404
5X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )A501 - 642
6X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )B15 - 383
7X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )B401
8X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )B402
9X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )B403
10X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )B501 - 624
11X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )C17 - 382
12X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )C401 - 402
13X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )C403
14X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )C404 - 405
15X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )C501 - 668
16X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )D14 - 383
17X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )D401
18X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )D402
19X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )D501 - 625
20X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )E16 - 382
21X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )E401
22X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )E402
23X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )E403 - 404
24X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )E501 - 627
25X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )F14 - 382
26X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )F401
27X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )F402
28X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )F403
29X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )F501 - 576
30X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )G14 - 382
31X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )G401 - 403
32X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )G404
33X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )G405 - 406
34X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )G501 - 612
35X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )H14 - 383
36X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )H401
37X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )H402
38X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )H501 - 602

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万見について

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お知らせ

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2022年2月9日: EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

  • EMDBのヘッダファイルのバージョン3が、公式のフォーマットとなりました。
  • これまでは公式だったバージョン1.9は、アーカイブから削除されます。

関連情報:EMDBヘッダ

外部リンク:wwPDBはEMDBデータモデルのバージョン3へ移行します

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2020年8月12日: 新型コロナ情報

新型コロナ情報

URL: https://pdbjlvh1.pdbj.org/emnavi/covid19.php

新ページ: EM Navigatorに新型コロナウイルスの特設ページを開設しました。

関連情報:Covid-19情報 / 2020年3月5日: 新型コロナウイルスの構造データ

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2020年3月5日: 新型コロナウイルスの構造データ

新型コロナウイルスの構造データ

関連情報:万見生物種 / 2020年8月12日: 新型コロナ情報

外部リンク:COVID-19特集ページ - PDBj / 今月の分子2020年2月：コロナウイルスプロテーアーゼ

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2019年1月31日: EMDBのIDの桁数の変更

EMDBのIDの桁数の変更

  • EMDBエントリに付与されているアクセスコード(EMDB-ID)は4桁の数字(例、EMD-1234)でしたが、間もなく枯渇します。これまでの4桁のID番号は4桁のまま変更されませんが、4桁の数字を使い切った後に発行されるIDは5桁以上の数字(例、EMD-12345)になります。5桁のIDは2019年の春頃から発行される見通しです。
  • EM Navigator/万見では、接頭語「EMD-」は省略されています。

関連情報:Q: 「EMD」とは何ですか？ / 万見/EM NavigatorにおけるID/アクセスコードの表記

外部リンク:EMDB Accession Codes are Changing Soon! / PDBjへお問い合わせ

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2017年7月12日: PDB大規模アップデート

PDB大規模アップデート

  • 新バージョンのPDBx/mmCIF辞書形式に基づくデータがリリースされました。
  • 今回の更新はバージョン番号が4から5になる大規模なもので、全エントリデータの書き換えが行われる「Remediation」というアップデートに該当します。
  • このバージョンアップで、電子顕微鏡の実験手法に関する多くの項目の書式が改定されました(例：em_softwareなど)。
  • EM NavigatorとYorodumiでも、この改定に基づいた表示内容になります。

外部リンク:wwPDB Remediation / OneDepデータ基準に準拠した、より強化された内容のモデル構造ファイルが、PDBアーカイブで公開されました。

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万見 (Yorodumi)

幾万の構造データを、幾万の視点から

  • 万見(Yorodumi)は、EMDB/PDB/SASBDBなどの構造データを閲覧するためのページです。
  • EM Navigatorの詳細ページの後継、Omokage検索のフロントエンドも兼ねています。

関連情報:EMDB / PDB / SASBDB / 3つのデータバンクの比較 / 万見検索 / 2016年8月31日: 新しいEM Navigatorと万見 / 万見文献 / Jmol/JSmol / 機能・相同性情報 / 新しいEM Navigatorと万見の変更点

他の情報も見る