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- PDB-8fmh: Structure of CBASS Cap5 from Pseudomonas syringae as an activated... -

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Basic information

Entry
Database: PDB / ID: 8fmh
TitleStructure of CBASS Cap5 from Pseudomonas syringae as an activated tetramer with the cyclic dinucleotide 3'2'-c-dGAMP ligand (2 tetramers in the AU)
ComponentsSAVED domain-containing protein
KeywordsIMMUNE SYSTEM / cyclic dinucleotide / bacterial immunity / CBASS / Cap5 effector DNA endonuclease / viral defense
Function / homologyHNH endonuclease / SMODS-associated and fused to various effectors / SMODS-associated and fused to various effectors sensor domain / HNH nuclease / 3'2'-cGAMP / DI(HYDROXYETHYL)ETHER / TRIETHYLENE GLYCOL / HNH endonuclease
Function and homology information
Biological speciesPseudomonas syringae (bacteria)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.87 Å
AuthorsRechkoblit, O. / Kreitler, D.F. / Aggarwal, A.K.
Funding support United States, 1items
OrganizationGrant numberCountry
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)GM13170 United States
CitationJournal: Nat.Struct.Mol.Biol. / Year: 2024
Title: Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides.
Authors: Rechkoblit, O. / Sciaky, D. / Kreitler, D.F. / Buku, A. / Kottur, J. / Aggarwal, A.K.
History
DepositionDec 23, 2022Deposition site: RCSB / Processing site: RCSB
Revision 1.0Feb 7, 2024Provider: repository / Type: Initial release
Revision 1.1Feb 21, 2024Group: Database references / Category: citation / Item: _citation.pdbx_database_id_PubMed / _citation.title
Revision 1.2May 29, 2024Group: Database references / Category: citation / citation_author
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: SAVED domain-containing protein
B: SAVED domain-containing protein
C: SAVED domain-containing protein
D: SAVED domain-containing protein
E: SAVED domain-containing protein
F: SAVED domain-containing protein
G: SAVED domain-containing protein
H: SAVED domain-containing protein
hetero molecules


Theoretical massNumber of molelcules
Total (without water)348,66437
Polymers342,1548
Non-polymers6,51029
Water17,583976
1
A: SAVED domain-containing protein
B: SAVED domain-containing protein
C: SAVED domain-containing protein
D: SAVED domain-containing protein
hetero molecules


Theoretical massNumber of molelcules
Total (without water)174,30818
Polymers171,0774
Non-polymers3,23114
Water724
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area18760 Å2
ΔGint-95 kcal/mol
Surface area53290 Å2
MethodPISA
2
E: SAVED domain-containing protein
F: SAVED domain-containing protein
G: SAVED domain-containing protein
H: SAVED domain-containing protein
hetero molecules


Theoretical massNumber of molelcules
Total (without water)174,35619
Polymers171,0774
Non-polymers3,27915
Water724
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area19780 Å2
ΔGint-88 kcal/mol
Surface area52560 Å2
MethodPISA
Unit cell
Length a, b, c (Å)67.970, 295.678, 84.052
Angle α, β, γ (deg.)90.000, 113.790, 90.000
Int Tables number4
Space group name H-MP1211
Space group name HallP2yb
Symmetry operation#1: x,y,z
#2: -x,y+1/2,-z

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Components

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Protein , 1 types, 8 molecules ABCDEFGH

#1: Protein
SAVED domain-containing protein / CBASS Cap5


Mass: 42769.238 Da / Num. of mol.: 8
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Pseudomonas syringae (bacteria) / Production host: Escherichia coli (E. coli) / References: UniProt: A0A2P0QGK5

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Non-polymers , 7 types, 1005 molecules

#2: Chemical
ChemComp-4UR / 3'2'-cGAMP / 2-amino-9-[(2S,5R,7R,8R,10R,12aR,14R,15R,15aS,16R)-7-(6-amino-9H-purin-9-yl)-2,10,15,16-tetrahydroxy-2,10-dioxidooctahydro-12H-5,8-methanofuro[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecin-14-yl]-1,9-dihydro-6H-purin-6-one


Mass: 674.411 Da / Num. of mol.: 8 / Source method: obtained synthetically / Formula: C20H24N10O13P2 / Feature type: SUBJECT OF INVESTIGATION
#3: Chemical
ChemComp-ZN / ZINC ION


Mass: 65.409 Da / Num. of mol.: 8 / Source method: obtained synthetically / Formula: Zn
#4: Chemical
ChemComp-MG / MAGNESIUM ION


Mass: 24.305 Da / Num. of mol.: 10 / Source method: obtained synthetically / Formula: Mg
#5: Chemical ChemComp-PGE / TRIETHYLENE GLYCOL


Mass: 150.173 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C6H14O4
#6: Chemical ChemComp-PEG / DI(HYDROXYETHYL)ETHER


Mass: 106.120 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C4H10O3
#7: Chemical ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL


Mass: 92.094 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C3H8O3
#8: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 976 / Source method: isolated from a natural source / Formula: H2O

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Details

Has ligand of interestY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.26 Å3/Da / Density % sol: 45.55 %
Crystal growTemperature: 293 K / Method: vapor diffusion, hanging drop
Details: 0.1 M Bis-Tris, pH 5.5-6.0, 0.2 M magnesium chloride, 19-20% PEG3350
PH range: 5.5-6.0

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: NSLS-II / Beamline: 17-ID-1 / Wavelength: 0.920105 Å
DetectorType: DECTRIS EIGER2 S 9M / Detector: PIXEL / Date: Mar 21, 2022
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.920105 Å / Relative weight: 1
ReflectionResolution: 1.87→147.839 Å / Num. obs: 151543 / % possible obs: 93.6 % / Redundancy: 4 % / Biso Wilson estimate: 29.27 Å2 / CC1/2: 0.994 / Rmerge(I) obs: 0.125 / Net I/σ(I): 6.9
Reflection shellResolution: 1.871→2.112 Å / Rmerge(I) obs: 0.753 / Num. unique obs: 7577 / CC1/2: 0.644

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Processing

Software
NameVersionClassification
PHENIX1.20.1_4487refinement
PHENIX1.20.1_4487refinement
XDSdata reduction
Aimlessdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: PDB entry 8FMF

8fmf


Resolution: 1.87→38.45 Å / SU ML: 0.2671 / Cross valid method: FREE R-VALUE / σ(F): 1.36 / Phase error: 34.0032
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflection
Rfree0.2533 7516 4.96 %
Rwork0.2098 143973 -
obs0.212 151489 61.05 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.1 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 53.54 Å2
Refinement stepCycle: LAST / Resolution: 1.87→38.45 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms22017 0 401 976 23394
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.003222977
X-RAY DIFFRACTIONf_angle_d0.614731444
X-RAY DIFFRACTIONf_chiral_restr0.04193554
X-RAY DIFFRACTIONf_plane_restr0.00554136
X-RAY DIFFRACTIONf_dihedral_angle_d14.42688554
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
1.87-1.890.214880.2818190X-RAY DIFFRACTION2.41
1.89-1.910.2485100.2907279X-RAY DIFFRACTION3.52
1.91-1.940.39150.3128346X-RAY DIFFRACTION4.39
1.94-1.960.3877190.3189437X-RAY DIFFRACTION5.53
1.96-1.990.2517360.2841635X-RAY DIFFRACTION8.16
1.99-2.020.3366250.3019895X-RAY DIFFRACTION11.19
2.02-2.040.3566530.29051152X-RAY DIFFRACTION14.48
2.04-2.080.3257850.29551356X-RAY DIFFRACTION17.57
2.08-2.110.3141870.29311679X-RAY DIFFRACTION21.3
2.11-2.140.253900.28121976X-RAY DIFFRACTION25.12
2.14-2.180.30791550.27792423X-RAY DIFFRACTION31.29
2.18-2.220.32171450.27573108X-RAY DIFFRACTION39.24
2.22-2.260.29751970.27114039X-RAY DIFFRACTION51.12
2.26-2.310.30672760.27585006X-RAY DIFFRACTION64.69
2.31-2.360.32352860.26265789X-RAY DIFFRACTION73.07
2.36-2.410.29663140.26746343X-RAY DIFFRACTION80.04
2.41-2.470.33673620.26846707X-RAY DIFFRACTION85.8
2.47-2.540.3083870.25757425X-RAY DIFFRACTION94.3
2.54-2.610.30463910.26037820X-RAY DIFFRACTION99.07
2.61-2.70.29084010.24837840X-RAY DIFFRACTION99.96
2.7-2.80.29474680.25147801X-RAY DIFFRACTION99.99
2.8-2.910.28323890.24247899X-RAY DIFFRACTION99.96
2.91-3.040.27384290.22217789X-RAY DIFFRACTION99.79
3.04-3.20.24213930.21417866X-RAY DIFFRACTION99.81
3.2-3.40.26373710.20247940X-RAY DIFFRACTION99.88
3.4-3.660.23954190.19087869X-RAY DIFFRACTION99.82
3.66-4.030.21634380.1697794X-RAY DIFFRACTION99.55
4.03-4.610.20744380.14927786X-RAY DIFFRACTION99.72
4.61-5.810.20933810.17027925X-RAY DIFFRACTION99.87
5.81-38.450.23134480.20367859X-RAY DIFFRACTION99.37
Refinement TLS params.Method: refined / Origin x: 16.928 Å / Origin y: 102.926 Å / Origin z: 17.449 Å
111213212223313233
T0.142835807555 Å20.0810613797245 Å20.00651310129596 Å2-0.235453818678 Å20.00515011844351 Å2--0.140024499368 Å2
L0.172319477197 °2-0.136568907731 °20.0559777518991 °2-0.911319807167 °20.0315996816898 °2--0.285770012244 °2
S-0.034392772543 Å °-0.0274169268225 Å °0.0241295245414 Å °0.228950734018 Å °0.0342213745307 Å °-0.171237867691 Å °-0.00765679729233 Å °-0.0602195022992 Å °0.002121977337 Å °
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )A14 - 382
2X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )A401
3X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )A402
4X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )A403 - 404
5X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )A501 - 642
6X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )B15 - 383
7X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )B401
8X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )B402
9X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )B403
10X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )B501 - 624
11X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )C17 - 382
12X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )C401 - 402
13X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )C403
14X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )C404 - 405
15X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )C501 - 668
16X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )D14 - 383
17X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )D401
18X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )D402
19X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )D501 - 625
20X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )E16 - 382
21X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )E401
22X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )E402
23X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )E403 - 404
24X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )E501 - 627
25X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )F14 - 382
26X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )F401
27X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )F402
28X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )F403
29X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )F501 - 576
30X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )G14 - 382
31X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )G401 - 403
32X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )G404
33X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )G405 - 406
34X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )G501 - 612
35X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )H14 - 383
36X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )H401
37X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )H402
38X-RAY DIFFRACTION1( CHAIN A AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:642 ) ) OR ( CHAIN B AND ( RESID 15:383 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:624 ) ) OR ( CHAIN C AND ( RESID 17:382 OR RESID 401:402 OR RESID 403:403 OR RESID 404:405 OR RESID 501:668 ) ) OR ( CHAIN D AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:625 ) ) OR ( CHAIN E AND ( RESID 16:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:404 OR RESID 501:627 ) ) OR ( CHAIN F AND ( RESID 14:382 OR RESID 401:401 OR RESID 402:402 OR RESID 403:403 OR RESID 501:576 ) ) OR ( CHAIN G AND ( RESID 14:382 OR RESID 401:403 OR RESID 404:404 OR RESID 405:406 OR RESID 501:612 ) ) OR ( CHAIN H AND ( RESID 14:383 OR RESID 401:401 OR RESID 402:402 OR RESID 501:602 ) )H501 - 602

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