+データを開く
-基本情報
登録情報 | データベース: PDB / ID: 8euq | ||||||
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タイトル | Crystal structure of HLA-DRA*01:01/HLA-DRB1*04:01 in complex with c44H10 Fab | ||||||
要素 |
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キーワード | IMMUNE SYSTEM / MHC class II / HLA-DR / Antibody | ||||||
機能・相同性 | 機能・相同性情報 myeloid dendritic cell antigen processing and presentation / antigen processing and presentation of endogenous peptide antigen via MHC class II / autolysosome membrane / regulation of T-helper cell differentiation / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / MHC class II receptor activity / positive regulation of CD4-positive, alpha-beta T cell activation / antigen processing and presentation of peptide or polysaccharide antigen via MHC class II / positive regulation of memory T cell differentiation / transport vesicle membrane ...myeloid dendritic cell antigen processing and presentation / antigen processing and presentation of endogenous peptide antigen via MHC class II / autolysosome membrane / regulation of T-helper cell differentiation / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / MHC class II receptor activity / positive regulation of CD4-positive, alpha-beta T cell activation / antigen processing and presentation of peptide or polysaccharide antigen via MHC class II / positive regulation of memory T cell differentiation / transport vesicle membrane / polysaccharide binding / Translocation of ZAP-70 to Immunological synapse / Phosphorylation of CD3 and TCR zeta chains / Generation of second messenger molecules / immunological synapse / PD-1 signaling / T cell receptor binding / MHC class II antigen presentation / trans-Golgi network membrane / lumenal side of endoplasmic reticulum membrane / clathrin-coated endocytic vesicle membrane / ER to Golgi transport vesicle membrane / cognition / peptide antigen assembly with MHC class II protein complex / MHC class II protein complex / positive regulation of T cell mediated cytotoxicity / peptide antigen binding / antigen processing and presentation of exogenous peptide antigen via MHC class II / endocytic vesicle membrane / Interferon gamma signaling / positive regulation of immune response / Downstream TCR signaling / positive regulation of T cell activation / MHC class II protein complex binding / late endosome membrane / early endosome membrane / clathrin-dependent endocytosis of virus by host cell / adaptive immune response / lysosome / endosome membrane / host cell surface receptor binding / immune response / Golgi membrane / lysosomal membrane / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / host cell plasma membrane / virion membrane / cell surface / extracellular exosome / membrane / plasma membrane 類似検索 - 分子機能 | ||||||
生物種 | Homo sapiens (ヒト) Influenza A virus (A型インフルエンザウイルス) | ||||||
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.09 Å | ||||||
データ登録者 | Kassardjian, A. / Julien, J.-P. | ||||||
資金援助 | カナダ, 1件
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引用 | ジャーナル: Cell Rep / 年: 2023 タイトル: Modular adjuvant-free pan-HLA-DR-immunotargeting subunit vaccine against SARS-CoV-2 elicits broad sarbecovirus-neutralizing antibody responses. 著者: Kassardjian, A. / Sun, E. / Sookhoo, J. / Muthuraman, K. / Boligan, K.F. / Kucharska, I. / Rujas, E. / Jetha, A. / Branch, D.R. / Babiuk, S. / Barber, B. / Julien, J.P. | ||||||
履歴 |
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-構造の表示
構造ビューア | 分子: MolmilJmol/JSmol |
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-ダウンロードとリンク
-ダウンロード
PDBx/mmCIF形式 | 8euq.cif.gz | 800.6 KB | 表示 | PDBx/mmCIF形式 |
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PDB形式 | pdb8euq.ent.gz | 558.9 KB | 表示 | PDB形式 |
PDBx/mmJSON形式 | 8euq.json.gz | ツリー表示 | PDBx/mmJSON形式 | |
その他 | その他のダウンロード |
-検証レポート
文書・要旨 | 8euq_validation.pdf.gz | 1 MB | 表示 | wwPDB検証レポート |
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文書・詳細版 | 8euq_full_validation.pdf.gz | 1 MB | 表示 | |
XML形式データ | 8euq_validation.xml.gz | 56 KB | 表示 | |
CIF形式データ | 8euq_validation.cif.gz | 75.1 KB | 表示 | |
アーカイブディレクトリ | https://data.pdbj.org/pub/pdb/validation_reports/eu/8euq ftp://data.pdbj.org/pub/pdb/validation_reports/eu/8euq | HTTPS FTP |
-関連構造データ
関連構造データ | 1aj7S 1dlhS S: 精密化の開始モデル |
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類似構造データ | 類似検索 - 機能・相同性F&H 検索 |
-リンク
-集合体
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非結晶学的対称性 (NCS) | NCSドメイン:
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