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TitleModular adjuvant-free pan-HLA-DR-immunotargeting subunit vaccine against SARS-CoV-2 elicits broad sarbecovirus-neutralizing antibody responses.
Journal, issue, pagesCell Rep, Vol. 42, Page 112391-112391, Year 2023
Publish dateOct 19, 2022 (structure data deposition date)
AuthorsKassardjian, A. / Sun, E. / Sookhoo, J. / Muthuraman, K. / Boligan, K.F. / Kucharska, I. / Rujas, E. / Jetha, A. / Branch, D.R. / Babiuk, S. ...Kassardjian, A. / Sun, E. / Sookhoo, J. / Muthuraman, K. / Boligan, K.F. / Kucharska, I. / Rujas, E. / Jetha, A. / Branch, D.R. / Babiuk, S. / Barber, B. / Julien, J.P.
External linksCell Rep / PubMed:37053069
MethodsX-ray diffraction
Resolution3.09 Å
Structure data

PDB-8euq:
Crystal structure of HLA-DRA*01:01/HLA-DRB1*04:01 in complex with c44H10 Fab
Method: X-RAY DIFFRACTION / Resolution: 3.09 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • influenza a virus
KeywordsIMMUNE SYSTEM / MHC class II / HLA-DR / Antibody

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