登録情報 | データベース: PDB / ID: 8dk4 |
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タイトル | Peroxisome proliferator-activated receptor gamma in complex with VSP-51-2 |
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要素 | - Peroxisome proliferator-activated receptor gamma
- Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
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キーワード | SIGNALING PROTEIN / Peroxisome proliferator-activated receptor gamma / Modulator / VSP-51-2 |
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機能・相同性 | 機能・相同性情報
Regulation of MITF-M dependent genes involved in metabolism / positive regulation of fatty acid oxidation / prostaglandin receptor activity / negative regulation of connective tissue replacement involved in inflammatory response wound healing / negative regulation of receptor signaling pathway via STAT / MECP2 regulates transcription factors / Activation of PPARGC1A (PGC-1alpha) by phosphorylation / negative regulation of extracellular matrix assembly / response to muscle activity / negative regulation of vascular endothelial cell proliferation ...Regulation of MITF-M dependent genes involved in metabolism / positive regulation of fatty acid oxidation / prostaglandin receptor activity / negative regulation of connective tissue replacement involved in inflammatory response wound healing / negative regulation of receptor signaling pathway via STAT / MECP2 regulates transcription factors / Activation of PPARGC1A (PGC-1alpha) by phosphorylation / negative regulation of extracellular matrix assembly / response to muscle activity / negative regulation of vascular endothelial cell proliferation / positive regulation of cholesterol transport / negative regulation of cardiac muscle hypertrophy in response to stress / negative regulation of cellular response to transforming growth factor beta stimulus / positive regulation of low-density lipoprotein receptor activity / arachidonate binding / cellular respiration / positive regulation of adiponectin secretion / lipoprotein transport / negative regulation of sequestering of triglyceride / lncRNA binding / DNA binding domain binding / macrophage derived foam cell differentiation / positive regulation of vascular associated smooth muscle cell apoptotic process / WW domain binding / temperature homeostasis / STAT family protein binding / positive regulation of fatty acid metabolic process / response to lipid / negative regulation of SMAD protein signal transduction / LBD domain binding / response to starvation / negative regulation of type II interferon-mediated signaling pathway / negative regulation of cholesterol storage / E-box binding / intracellular glucose homeostasis / alpha-actinin binding / lipid homeostasis / fatty acid oxidation / negative regulation of vascular associated smooth muscle cell proliferation / R-SMAD binding / monocyte differentiation / response to dietary excess / negative regulation of blood vessel endothelial cell migration / negative regulation of macrophage derived foam cell differentiation / negative regulation of lipid storage / cellular response to low-density lipoprotein particle stimulus / white fat cell differentiation / negative regulation of BMP signaling pathway / cell fate commitment / positive regulation of cholesterol efflux / negative regulation of mitochondrial fission / positive regulation of fat cell differentiation / negative regulation of osteoblast differentiation / negative regulation of MAPK cascade / BMP signaling pathway / adipose tissue development / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / retinoic acid receptor signaling pathway / long-chain fatty acid transport / nuclear retinoid X receptor binding / brown fat cell differentiation / Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 / energy homeostasis / cell maturation / epithelial cell differentiation / positive regulation of gluconeogenesis / negative regulation of signaling receptor activity / digestion / positive regulation of adipose tissue development / peroxisome proliferator activated receptor signaling pathway / hormone-mediated signaling pathway / regulation of cellular response to insulin stimulus / negative regulation of angiogenesis / RNA splicing / respiratory electron transport chain / response to nutrient / negative regulation of miRNA transcription / SUMOylation of transcription cofactors / nuclear receptor coactivator activity / Regulation of PTEN gene transcription / gluconeogenesis / transcription coregulator binding / fatty acid metabolic process / mitochondrion organization / nuclear receptor binding / transcription initiation at RNA polymerase II promoter / negative regulation of smooth muscle cell proliferation / positive regulation of DNA-binding transcription factor activity / transcription coregulator activity / positive regulation of apoptotic signaling pathway / negative regulation of transforming growth factor beta receptor signaling pathway / circadian regulation of gene expression / peptide binding / SUMOylation of intracellular receptors / Heme signaling / mRNA transcription by RNA polymerase II / regulation of circadian rhythm / Transcriptional activation of mitochondrial biogenesis / placenta development / PPARA activates gene expression類似検索 - 分子機能 PGC-1alpha, RNA recognition motif / PGC-1 / Peroxisome proliferator-activated receptor gamma / Peroxisome proliferator-activated receptor gamma, N-terminal / PPAR gamma N-terminal region / Peroxisome proliferator-activated receptor / : / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. ...PGC-1alpha, RNA recognition motif / PGC-1 / Peroxisome proliferator-activated receptor gamma / Peroxisome proliferator-activated receptor gamma, N-terminal / PPAR gamma N-terminal region / Peroxisome proliferator-activated receptor / : / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / Nuclear hormone receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Nucleotide-binding alpha-beta plait domain superfamily類似検索 - ドメイン・相同性 Chem-SJ9 / Peroxisome proliferator-activated receptor gamma / Peroxisome proliferator-activated receptor gamma coactivator 1-alpha類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.6 Å |
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データ登録者 | Ma, L. / Zhou, X.E. / Suino-Powell, K. / Hou, N. / Zhou, Z. / Luo, J. / Xu, H.E. / Yi, W. |
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資金援助 | 中国, 2件 組織 | 認可番号 | 国 |
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National Science Foundation (NSF, China) | 21877020 | 中国 | National Science Foundation (NSF, China) | 22007020 | 中国 |
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引用 | ジャーナル: To Be Published タイトル: Identification of VSP-51-2 as the Novel and Safe PPAR gamma Modulator: Structure-Based Design, Biological Validation and Crystal Analysis 著者: Ma, L. / Zhou, X.E. / Suino-Powell, K. / Hou, N. / Zhou, Z. / Luo, J. / Xu, H.E. / Yi, W. |
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履歴 | 登録 | 2022年7月2日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年7月5日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月25日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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