登録情報 | データベース: PDB / ID: 8cz9 |
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タイトル | Crystal Structure of the E372K LNK SH2 Domain mutant in Complex with a JAK2 pY813 Phosphopeptide |
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要素 | - JAK2 pY813 phosphopeptide
- SH2B adapter protein 3
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キーワード | SIGNALING PROTEIN / LNK / SH2B3 / JAK/STAT / MPNs |
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機能・相同性 | 機能・相同性情報
negative regulation of Kit signaling pathway / monocyte homeostasis / thrombopoietin-mediated signaling pathway / stem cell factor receptor binding / negative regulation of sprouting angiogenesis / negative regulation of chemokine-mediated signaling pathway / negative regulation of response to cytokine stimulus / negative regulation of tyrosine phosphorylation of STAT protein / regulation of regulatory T cell differentiation / negative regulation of receptor signaling pathway via JAK-STAT ...negative regulation of Kit signaling pathway / monocyte homeostasis / thrombopoietin-mediated signaling pathway / stem cell factor receptor binding / negative regulation of sprouting angiogenesis / negative regulation of chemokine-mediated signaling pathway / negative regulation of response to cytokine stimulus / negative regulation of tyrosine phosphorylation of STAT protein / regulation of regulatory T cell differentiation / negative regulation of receptor signaling pathway via JAK-STAT / negative regulation of platelet aggregation / neutrophil homeostasis / cellular response to chemokine / cellular response to interleukin-3 / embryonic hemopoiesis / megakaryocyte development / phosphate ion binding / hemopoiesis / hematopoietic stem cell differentiation / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / erythrocyte development / protein tyrosine kinase binding / negative regulation of MAP kinase activity / signaling receptor complex adaptor activity / cell differentiation / intracellular signal transduction / negative regulation of cell population proliferation / protein-containing complex binding類似検索 - 分子機能 SH2B3, SH2 domain / SH2B adapter protein / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / SH2 domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Mus musculus (ハツカネズミ) Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.65 Å |
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データ登録者 | Morris, R. / Kershaw, N.J. / Babon, J.J. |
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資金援助 | オーストラリア, 1件 組織 | 認可番号 | 国 |
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National Health and Medical Research Council (NHMRC, Australia) | | オーストラリア |
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引用 | ジャーナル: J.Exp.Med. / 年: 2024 タイトル: Rare SH2B3 coding variants in lupus patients impair B cell tolerance and predispose to autoimmunity. 著者: Zhang, Y. / Morris, R. / Brown, G.J. / Lorenzo, A.M.D. / Meng, X. / Kershaw, N.J. / Kiridena, P. / Burgio, G. / Gross, S. / Cappello, J.Y. / Shen, Q. / Wang, H. / Turnbull, C. / Lea-Henry, T. ...著者: Zhang, Y. / Morris, R. / Brown, G.J. / Lorenzo, A.M.D. / Meng, X. / Kershaw, N.J. / Kiridena, P. / Burgio, G. / Gross, S. / Cappello, J.Y. / Shen, Q. / Wang, H. / Turnbull, C. / Lea-Henry, T. / Stanley, M. / Yu, Z. / Ballard, F.D. / Chuah, A. / Lee, J.C. / Hatch, A.M. / Enders, A. / Masters, S.L. / Headley, A.P. / Trnka, P. / Mallon, D. / Fletcher, J.T. / Walters, G.D. / Sestan, M. / Jelusic, M. / Cook, M.C. / Athanasopoulos, V. / Fulcher, D.A. / Babon, J.J. / Vinuesa, C.G. / Ellyard, J.I. |
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履歴 | 登録 | 2022年5月24日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年5月31日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月25日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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改定 1.2 | 2023年11月15日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond / Item: _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2 |
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改定 1.3 | 2024年3月13日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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