Entry Database : PDB / ID : 8ckk Structure visualization Downloads & linksTitle Semaphorin-5A TSR 3-4 domains in complex with nitrate ComponentsSemaphorin-5A Details Keywords SIGNALING PROTEIN / semaphorin / cell signalling / axon guidance cue / glycosaminoglycan binding proteinFunction / homology Function and homology informationFunction Domain/homology Component
signal clustering / diencephalon development / chondroitin sulfate proteoglycan binding / semaphorin receptor binding / positive regulation of actin filament depolymerization / Defective B3GALTL causes PpS / O-glycosylation of TSR domain-containing proteins / Other semaphorin interactions / negative regulation of axon extension involved in axon guidance / syndecan binding ... signal clustering / diencephalon development / chondroitin sulfate proteoglycan binding / semaphorin receptor binding / positive regulation of actin filament depolymerization / Defective B3GALTL causes PpS / O-glycosylation of TSR domain-containing proteins / Other semaphorin interactions / negative regulation of axon extension involved in axon guidance / syndecan binding / blood vessel endothelial cell proliferation involved in sprouting angiogenesis / positive regulation of axon extension involved in axon guidance / chemorepellent activity / negative regulation of cell adhesion / axon extension / heparan sulfate proteoglycan binding / axonal fasciculation / neural crest cell migration / positive regulation of endothelial cell chemotaxis / positive chemotaxis / semaphorin-plexin signaling pathway / negative regulation of endothelial cell apoptotic process / positive regulation of endothelial cell proliferation / cell chemotaxis / axon guidance / positive regulation of angiogenesis / positive regulation of canonical Wnt signaling pathway / cell-cell signaling / nervous system development / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / cell adhesion / positive regulation of cell migration / extracellular exosome / membrane / plasma membrane Similarity search - Function Semaphorin-5A, sema domain / Semaphorin / Plexin repeat / Plexin repeat / Sema domain / semaphorin domain / Sema domain / Sema domain superfamily / Sema domain profile. / Thrombospondin type 1 domain ... Semaphorin-5A, sema domain / Semaphorin / Plexin repeat / Plexin repeat / Sema domain / semaphorin domain / Sema domain / Sema domain superfamily / Sema domain profile. / Thrombospondin type 1 domain / Thrombospondin type-1 (TSP1) repeat superfamily / Thrombospondin type-1 (TSP1) repeat profile. / Thrombospondin type 1 repeats / Thrombospondin type-1 (TSP1) repeat / PSI domain / domain found in Plexins, Semaphorins and Integrins / WD40/YVTN repeat-like-containing domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.56 Å DetailsAuthors Nagy, G.N. / Duman, R. / Harlos, K. / El Omari, K. / Wagner, A. / Jones, E.Y. Funding support United Kingdom, 1items Details Hide detailsOrganization Grant number Country Medical Research Council (MRC, United Kingdom) MR/T000503/1 United Kingdom
CitationJournal : To Be Published Title : Semaphorin-5A TSR 3-4 domains in complex with nitrateAuthors : Nagy, G.N. / Duman, R. / Harlos, K. / El Omari, K. / Wagner, A. / Jones, E.Y. History Deposition Feb 15, 2023 Deposition site : PDBE / Processing site : PDBERevision 1.0 Feb 28, 2024 Provider : repository / Type : Initial release