TRANSCRIPTION / transcription factor / DNA-binding protein / protein-DNA complex
Function / homology
Function and homology information
RUNX1 regulates transcription of genes involved in BCR signaling / RUNX1 regulates transcription of genes involved in interleukin signaling / canonical glycolysis / muscle organ development / negative regulation of T cell receptor signaling pathway / intracellular glucose homeostasis / response to starvation / regulation of glucose metabolic process / 14-3-3 protein binding / regulation of cytokine production ...RUNX1 regulates transcription of genes involved in BCR signaling / RUNX1 regulates transcription of genes involved in interleukin signaling / canonical glycolysis / muscle organ development / negative regulation of T cell receptor signaling pathway / intracellular glucose homeostasis / response to starvation / regulation of glucose metabolic process / 14-3-3 protein binding / regulation of cytokine production / negative regulation of autophagy / DNA-binding transcription repressor activity, RNA polymerase II-specific / UCH proteinases / sequence-specific double-stranded DNA binding / DNA-binding transcription activator activity, RNA polymerase II-specific / cell differentiation / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytoplasm Similarity search - Function
Transcription factor Elf, N-terminal / Transcription factor protein N terminal / : / Fork head domain conserved site1 / Fork head domain signature 1. / Fork head domain / Forkhead domain / Fork head domain profile. / FORKHEAD / Fork head domain conserved site 2 ...Transcription factor Elf, N-terminal / Transcription factor protein N terminal / : / Fork head domain conserved site1 / Fork head domain signature 1. / Fork head domain / Forkhead domain / Fork head domain profile. / FORKHEAD / Fork head domain conserved site 2 / Fork head domain signature 2. / Ets-domain signature 1. / ETS family / Ets-domain signature 2. / Ets domain / Ets-domain / Ets-domain profile. / erythroblast transformation specific domain / Forkhead associated domain / Forkhead-associated (FHA) domain profile. / FHA domain / Forkhead-associated (FHA) domain / SMAD/FHA domain superfamily / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily Similarity search - Domain/homology
G: DNA A: Forkhead box protein K1 E: Forkhead box protein K1 F: DNA C: DNA D: DNA I: Forkhead box protein K1 J: Forkhead box protein K1 B: ETS-related transcription factor Elf-1 H: ETS-related transcription factor Elf-1 hetero molecules
Method to determine structure: MOLECULAR REPLACEMENT / Resolution: 2.69→40 Å / Cor.coef. Fo:Fc: 0.942 / Cor.coef. Fo:Fc free: 0.889 / SU B: 46.509 / SU ML: 0.786 / Cross valid method: THROUGHOUT / ESU R Free: 0.475 / Stereochemistry target values: MAXIMUM LIKELIHOOD / Details: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
Num. reflection
% reflection
Selection details
Rfree
0.3236
1218
5.3 %
RANDOM
Rwork
0.27053
-
-
-
obs
0.27352
21947
96.43 %
-
Solvent computation
Ion probe radii: 0.8 Å / Shrinkage radii: 0.8 Å / VDW probe radii: 1.2 Å / Solvent model: MASK