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TitleDNA-guided transcription factor interactions extend human gene regulatory code.
Journal, issue, pagesNature, Year 2025
Publish dateOct 26, 2015 (structure data deposition date)
AuthorsXie, Z. / Sokolov, I. / Osmala, M. / Yue, X. / Bower, G. / Pett, J.P. / Chen, Y. / Wang, K. / Cavga, A.D. / Popov, A. ...Xie, Z. / Sokolov, I. / Osmala, M. / Yue, X. / Bower, G. / Pett, J.P. / Chen, Y. / Wang, K. / Cavga, A.D. / Popov, A. / Teichmann, S.A. / Morgunova, E. / Kvon, E.Z. / Yin, Y. / Taipale, J.
External linksNature / PubMed:40205063
MethodsX-ray diffraction
Resolution1.98 - 3.26 Å
Structure data

PDB-5eg0:
HOXB13-MEIS1 heterodimer bound to DNA
Method: X-RAY DIFFRACTION / Resolution: 3.101 Å

PDB-5no6:
TEAD4-HOXB13 complex bound to DNA
Method: X-RAY DIFFRACTION / Resolution: 2.88 Å

PDB-8byx:
HOXB13-homodimer bound to DNA
Method: X-RAY DIFFRACTION / Resolution: 3 Å

PDB-8bzm:
FOXK1-ELF1-heterodimer bound to DNA
Method: X-RAY DIFFRACTION / Resolution: 2.69 Å

PDB-8r7f:
Transcription factor BARHL2 homodimer with spacing two bp
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

PDB-8r7z:
transcription factor BARHL2 homodimer with spacing four bp
Method: X-RAY DIFFRACTION / Resolution: 3.26 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

ChemComp-NA:
Unknown entry

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsTRANSCRIPTION / transcription factor / heterodimer / complex / bound to DNA / DNA binding / DNA-binding protein / protein-DNA complex / homeobox protein / homodimer / complex with specific DNA

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