登録情報 | データベース: PDB / ID: 8bi2 |
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タイトル | Syk kinase domain in complex with macrocyclic inhibitor 20a |
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要素 | Tyrosine-protein kinase SYK |
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キーワード | TRANSFERASE (転移酵素) / SYK Kinase TRANSFERASE INHIBITOR |
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機能・相同性 | 機能・相同性情報
serotonin secretion by platelet / interleukin-15 receptor binding / positive regulation of interleukin-3 production / regulation of superoxide anion generation / regulation of neutrophil degranulation / regulation of arachidonic acid secretion / cellular response to lectin / gamma-delta T cell differentiation / positive regulation of gamma-delta T cell differentiation / B cell receptor complex ...serotonin secretion by platelet / interleukin-15 receptor binding / positive regulation of interleukin-3 production / regulation of superoxide anion generation / regulation of neutrophil degranulation / regulation of arachidonic acid secretion / cellular response to lectin / gamma-delta T cell differentiation / positive regulation of gamma-delta T cell differentiation / B cell receptor complex / neutrophil activation involved in immune response / Toll-like receptor binding / regulation of platelet aggregation / positive regulation of alpha-beta T cell proliferation / leukocyte activation involved in immune response / positive regulation of mast cell cytokine production / regulation of platelet activation / lymph vessel development / collagen-activated tyrosine kinase receptor signaling pathway / cell activation / positive regulation of mast cell degranulation / positive regulation of killing of cells of another organism / regulation of phagocytosis / beta selection / macrophage activation involved in immune response / leukotriene biosynthetic process / cellular response to molecule of fungal origin / FLT3 signaling through SRC family kinases / early phagosome / regulation of tumor necrosis factor-mediated signaling pathway / interleukin-3-mediated signaling pathway / cellular response to lipid / positive regulation of monocyte chemotactic protein-1 production / regulation of DNA-binding transcription factor activity / positive regulation of cell adhesion mediated by integrin / positive regulation of granulocyte macrophage colony-stimulating factor production / Fc epsilon receptor (FCERI) signaling / Interleukin-2 signaling / positive regulation of alpha-beta T cell differentiation / blood vessel morphogenesis / T cell receptor complex / positive regulation of B cell differentiation / leukocyte cell-cell adhesion / mast cell degranulation / Fc-gamma receptor signaling pathway involved in phagocytosis / positive regulation of interleukin-4 production / Dectin-2 family / Fc-epsilon receptor signaling pathway / stimulatory C-type lectin receptor signaling pathway / phospholipase binding / positive regulation of interleukin-10 production / positive regulation of receptor internalization / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / cellular response to low-density lipoprotein particle stimulus / FCGR activation / positive regulation of type I interferon production / phosphatase binding / positive regulation of bone resorption / Role of phospholipids in phagocytosis / Role of LAT2/NTAL/LAB on calcium mobilization / positive regulation of calcium-mediated signaling / Signaling by CSF3 (G-CSF) / negative regulation of inflammatory response to antigenic stimulus / GPVI-mediated activation cascade / positive regulation of TORC1 signaling / positive regulation of interleukin-12 production / phosphotyrosine residue binding / SH2 domain binding / Integrin signaling / FCERI mediated Ca+2 mobilization / B cell differentiation / 好中球 / FCGR3A-mediated IL10 synthesis / regulation of ERK1 and ERK2 cascade / positive regulation of superoxide anion generation / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / integrin-mediated signaling pathway / calcium-mediated signaling / positive regulation of interleukin-8 production / Regulation of signaling by CBL / FCERI mediated MAPK activation / FCGR3A-mediated phagocytosis / cell surface receptor protein tyrosine kinase signaling pathway / animal organ morphogenesis / B cell receptor signaling pathway / non-specific protein-tyrosine kinase / non-membrane spanning protein tyrosine kinase activity / positive regulation of protein-containing complex assembly / Inactivation of CSF3 (G-CSF) signaling / receptor internalization / Regulation of actin dynamics for phagocytic cup formation / 凝固・線溶系 / CLEC7A (Dectin-1) signaling / peptidyl-tyrosine phosphorylation / protein import into nucleus / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / positive regulation of peptidyl-tyrosine phosphorylation / integrin binding / DAP12 signaling類似検索 - 分子機能 Tyrosine-protein kinase, non-receptor SYK/ZAP-70 / Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily / SYK/ZAP-70, N-terminal SH2 domain / SH2ドメイン / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2ドメイン / SH2 domain superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain ...Tyrosine-protein kinase, non-receptor SYK/ZAP-70 / Tyrosine-protein kinase SYK/ZAP-70, inter-SH2 domain superfamily / SYK/ZAP-70, N-terminal SH2 domain / SH2ドメイン / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2ドメイン / SH2 domain superfamily / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | ![](img/tx_human.gif) Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.508 Å |
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データ登録者 | Read, J.A. / Patel, J. |
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資金援助 | 1件 |
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引用 | ジャーナル: Bioorg.Med.Chem.Lett. / 年: 2023 タイトル: Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors. 著者: Grimster, N.P. / Gingipalli, L. / Balazs, A. / Barlaam, B. / Boiko, S. / Boyd, S. / Dry, H. / Goldberg, F.W. / Ikeda, T. / Johnson, T. / Kawatkar, S. / Kemmitt, P. / Lamont, S. / Lorthioir, O. ...著者: Grimster, N.P. / Gingipalli, L. / Balazs, A. / Barlaam, B. / Boiko, S. / Boyd, S. / Dry, H. / Goldberg, F.W. / Ikeda, T. / Johnson, T. / Kawatkar, S. / Kemmitt, P. / Lamont, S. / Lorthioir, O. / Mfuh, A. / Patel, J. / Pike, A. / Read, J. / Romero, R. / Sarkar, U. / Sha, L. / Simpson, I. / Song, K. / Su, Q. / Wang, H. / Watson, D. / Wu, A. / Zehnder, T.E. / Zheng, X. / Li, S. / Dong, Z. / Yang, D. / Song, Y. / Wang, P. / Liu, X. / Dowling, J.E. / Edmondson, S.D. |
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履歴 | 登録 | 2022年11月1日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2023年6月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年6月21日 | Group: Database references / カテゴリ: citation / Item: _citation.journal_volume / _citation.title |
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改定 1.2 | 2024年5月1日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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