登録情報 | データベース: PDB / ID: 8b4w |
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タイトル | X-ray structure of furin (PCSK3) in complex with 1H-isoindol-3-amine |
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要素 | Furinフーリン (タンパク質) |
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キーワード | HYDROLASE (加水分解酵素) / furin (フーリン (タンパク質)) / proprotein convertase subtilisin/kexin type 3 / PCSK3 / SARS-CoV-2 (SARSコロナウイルス2) / inhibitor (酵素阻害剤) / protease (プロテアーゼ) / complex |
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機能・相同性 | 機能・相同性情報
フーリン (タンパク質) / nerve growth factor production / dibasic protein processing / plasma lipoprotein particle remodeling / NGF processing / Assembly of active LPL and LIPC lipase complexes / negative regulation of transforming growth factor beta1 production / signal peptide processing / regulation of cholesterol transport / peptide biosynthetic process ...フーリン (タンパク質) / nerve growth factor production / dibasic protein processing / plasma lipoprotein particle remodeling / NGF processing / Assembly of active LPL and LIPC lipase complexes / negative regulation of transforming growth factor beta1 production / signal peptide processing / regulation of cholesterol transport / peptide biosynthetic process / negative regulation of low-density lipoprotein particle receptor catabolic process / cytokine precursor processing / Pre-NOTCH Processing in Golgi / secretion by cell / Synthesis and processing of ENV and VPU / Formation of the cornified envelope / nerve growth factor binding / Signaling by PDGF / trans-Golgi network transport vesicle / Elastic fibre formation / blastocyst formation / Signaling by NODAL / heparan sulfate binding / regulation of endopeptidase activity / zymogen activation / peptide hormone processing / positive regulation of membrane protein ectodomain proteolysis / CD163 mediating an anti-inflammatory response / regulation of protein catabolic process / Activation of Matrix Metalloproteinases / TGF-beta receptor signaling activates SMADs / Uptake and function of anthrax toxins / protein maturation / Collagen degradation / collagen catabolic process / regulation of signal transduction / extracellular matrix disassembly / Removal of aminoterminal propeptides from gamma-carboxylated proteins / negative regulation of inflammatory response to antigenic stimulus / ウイルスのライフサイクル / serine-type peptidase activity / extracellular matrix organization / transforming growth factor beta receptor signaling pathway / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / peptide binding / ゴルジ体 / serine-type endopeptidase inhibitor activity / protein processing / Golgi lumen / heparin binding / peptidase activity / viral translation / endopeptidase activity / protease binding / Induction of Cell-Cell Fusion / Potential therapeutics for SARS / amyloid fibril formation / Attachment and Entry / positive regulation of viral entry into host cell / viral protein processing / endosome membrane / 脂質ラフト / Amyloid fiber formation / ゴルジ体 / serine-type endopeptidase activity / 細胞膜 / 小胞体 / extracellular exosome / extracellular region / 生体膜 / metal ion binding / 細胞膜類似検索 - 分子機能 Peptidase S8, pro-domain / Peptidase S8, pro-domain superfamily / Peptidase S8 pro-domain / Kexin/furin catalytic domain / P domain / Proprotein convertase P-domain / P/Homo B domain profile. / Peptidase S8, subtilisin, His-active site / Serine proteases, subtilase family, histidine active site. / Serine proteases, subtilase family, aspartic acid active site. ...Peptidase S8, pro-domain / Peptidase S8, pro-domain superfamily / Peptidase S8 pro-domain / Kexin/furin catalytic domain / P domain / Proprotein convertase P-domain / P/Homo B domain profile. / Peptidase S8, subtilisin, His-active site / Serine proteases, subtilase family, histidine active site. / Serine proteases, subtilase family, aspartic acid active site. / Peptidase S8, subtilisin, Asp-active site / Serine proteases, subtilase family, serine active site. / Peptidase S8, subtilisin, Ser-active site / Serine proteases, subtilase domain profile. / Peptidase S8, subtilisin-related / Furin-like repeat / Furin-like repeats / Peptidase S8/S53 domain superfamily / Subtilase family / Peptidase S8/S53 domain / Growth factor receptor cysteine-rich domain superfamily / Galactose-binding-like domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.6 Å |
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データ登録者 | Dahms, S.O. / Brandstetter, H. |
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資金援助 | オーストリア, 1件 組織 | 認可番号 | 国 |
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Austrian Science Fund | M 2730 | オーストリア |
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引用 | ジャーナル: Chemmedchem / 年: 2024 タイトル: Fragment-Based Design, Synthesis, and Characterization of Aminoisoindole-Derived Furin Inhibitors. 著者: Lange, R.W. / Bloch, K. / Heindl, M.R. / Wollenhaupt, J. / Weiss, M.S. / Brandstetter, H. / Klebe, G. / Falcone, F.H. / Bottcher-Friebertshauser, E. / Dahms, S.O. / Steinmetzer, T. |
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履歴 | 登録 | 2022年9月21日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2023年10月4日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年3月13日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2024年5月15日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation_author.identifier_ORCID |
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