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Open data
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Basic information
Entry | Database: PDB / ID: 7zez | ||||||
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Title | Trimolecular complex Cyp33-RRMdelta alpha : MLL1-PHD3 : H3K4me3 | ||||||
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![]() | TRANSCRIPTION / RRM / RNA BINDING PROTEIN-STRUCTURAL PROTEIN COMPLEX / HISTONE 3 / H3K4me3 / EPIGENETIC / MLL1 Transcription regulation / infant leukemia | ||||||
Function / homology | ![]() protein-cysteine methyltransferase activity / response to potassium ion / [histone H3]-lysine4 N-methyltransferase / histone H3K4 monomethyltransferase activity / unmethylated CpG binding / histone H3K4 trimethyltransferase activity / negative regulation of DNA methylation-dependent heterochromatin formation / poly(A) binding / regulation of short-term neuronal synaptic plasticity / T-helper 2 cell differentiation ...protein-cysteine methyltransferase activity / response to potassium ion / [histone H3]-lysine4 N-methyltransferase / histone H3K4 monomethyltransferase activity / unmethylated CpG binding / histone H3K4 trimethyltransferase activity / negative regulation of DNA methylation-dependent heterochromatin formation / poly(A) binding / regulation of short-term neuronal synaptic plasticity / T-helper 2 cell differentiation / definitive hemopoiesis / histone H3K4 methyltransferase activity / U2-type catalytic step 2 spliceosome / embryonic hemopoiesis / exploration behavior / anterior/posterior pattern specification / cyclosporin A binding / histone methyltransferase complex / Formation of WDR5-containing histone-modifying complexes / minor groove of adenine-thymine-rich DNA binding / membrane depolarization / MLL1 complex / positive regulation of viral genome replication / protein peptidyl-prolyl isomerization / negative regulation of fibroblast proliferation / homeostasis of number of cells within a tissue / spleen development / transcription initiation-coupled chromatin remodeling / cellular response to transforming growth factor beta stimulus / catalytic step 2 spliceosome / mRNA Splicing - Major Pathway / Transferases; Transferring one-carbon groups; Methyltransferases / post-embryonic development / peptidylprolyl isomerase / peptidyl-prolyl cis-trans isomerase activity / circadian regulation of gene expression / lysine-acetylated histone binding / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / visual learning / protein modification process / Transcription-Coupled Nucleotide Excision Repair (TC-NER) / Formation of TC-NER Pre-Incision Complex / PKMTs methylate histone lysines / mRNA splicing, via spliceosome / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / Transcriptional regulation of granulopoiesis / nucleosome / protein folding / RUNX1 regulates transcription of genes involved in differentiation of HSCs / fibroblast proliferation / methylation / protein-containing complex assembly / secretory granule lumen / ficolin-1-rich granule lumen / nuclear speck / protein heterodimerization activity / intracellular membrane-bounded organelle / mRNA binding / apoptotic process / chromatin binding / Neutrophil degranulation / regulation of DNA-templated transcription / positive regulation of DNA-templated transcription / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / DNA binding / RNA binding / zinc ion binding / extracellular region / nucleoplasm / identical protein binding / nucleus / plasma membrane / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | SOLUTION NMR / simulated annealing | ||||||
![]() | Blatter, M. / Allain, F. / Meylan, C. | ||||||
Funding support | ![]()
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![]() | ![]() Title: RNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription. Authors: Blatter, M. / Meylan, C. / Clery, A. / Giambruno, R. / Nikolaev, Y. / Heidecker, M. / Solanki, J.A. / Diaz, M.O. / Gabellini, D. / Allain, F.H. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 1 MB | Display | ![]() |
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PDB format | ![]() | 866.2 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 370.7 KB | Display | ![]() |
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Full document | ![]() | 689.3 KB | Display | |
Data in XML | ![]() | 63.3 KB | Display | |
Data in CIF | ![]() | 82 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 7zevC ![]() 7zewC ![]() 7zexC ![]() 7zeyC C: citing same article ( |
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Similar structure data | Similarity search - Function & homology ![]() |
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Assembly
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Components
#1: Protein | Mass: 10349.721 Da / Num. of mol.: 1 / Fragment: RRM (UNP RESIDUES 1-90) Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() | ||
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#2: Protein | Mass: 7437.360 Da / Num. of mol.: 1 / Fragment: PHD ZINC FINGER (UNP RESIDUES 1564-1627) Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() | ||
#3: Protein/peptide | Mass: 1407.620 Da / Num. of mol.: 1 / Fragment: N-TERMINAL TAIL (UNP RESIDUES 2-14) / Source method: obtained synthetically / Source: (synth.) ![]() | ||
#4: Chemical | Has ligand of interest | Y | |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Sample preparation
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