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Structure paper

TitleRNA binding induces an allosteric switch in Cyp33 to repress MLL1-mediated transcription.
Journal, issue, pagesSci Adv, Vol. 9, Page eadf5330-eadf5330, Year 2023
Publish dateMar 31, 2022 (structure data deposition date)
AuthorsBlatter, M. / Meylan, C. / Clery, A. / Giambruno, R. / Nikolaev, Y. / Heidecker, M. / Solanki, J.A. / Diaz, M.O. / Gabellini, D. / Allain, F.H.
External linksSci Adv / PubMed:37075125
MethodsNMR (solution)
Structure data

PDB-7zev:
Free form of extended Cyp33-RRM
Method: SOLUTION NMR

PDB-7zew:
Complex Cyp33-RRM : AAUAAA RNA
Method: SOLUTION NMR

PDB-7zex:
Complex Cyp33-RRMdelta alpha : UAAUGUCG RNA
Method: SOLUTION NMR

PDB-7zey:
Complex Cyp33-RRM : MLL1-PHD3
Method: SOLUTION NMR

PDB-7zez:
Trimolecular complex Cyp33-RRMdelta alpha : MLL1-PHD3 : H3K4me3
Method: SOLUTION NMR

Chemicals

ChemComp-ZN:
Unknown entry

Source
  • homo sapiens (human)
KeywordsTRANSCRIPTION / RRM / RNA BINDING PROTEIN-STRUCTURAL PROTEIN COMPLEX / HISTONE 3 / H3K4me3 / EPIGENETIC / MLL1 Transcription regulation / infant leukemia

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