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Yorodumi- PDB-7z50: Structure of the highly diabetogenic 4.1-T cell receptor targetin... -
+Open data
-Basic information
Entry | Database: PDB / ID: 7z50 | ||||||||||||
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Title | Structure of the highly diabetogenic 4.1-T cell receptor targeting a hybrid insulin peptide bound to I-Ag7. | ||||||||||||
Components |
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Keywords | IMMUNE SYSTEM / Diabetes / T cell receptor / murine MHC class II / hybrid insulin peptide | ||||||||||||
Function / homology | Function and homology information antigen processing and presentation of peptide antigen / positive regulation of T cell differentiation / antigen processing and presentation / negative regulation of T cell proliferation / multivesicular body / peptide antigen assembly with MHC class II protein complex / MHC class II protein complex / peptide antigen binding / antigen processing and presentation of exogenous peptide antigen via MHC class II / positive regulation of immune response ...antigen processing and presentation of peptide antigen / positive regulation of T cell differentiation / antigen processing and presentation / negative regulation of T cell proliferation / multivesicular body / peptide antigen assembly with MHC class II protein complex / MHC class II protein complex / peptide antigen binding / antigen processing and presentation of exogenous peptide antigen via MHC class II / positive regulation of immune response / positive regulation of T cell activation / MHC class II protein complex binding / late endosome membrane / adaptive immune response / lysosome / early endosome / lysosomal membrane / external side of plasma membrane / protein-containing complex binding / Golgi apparatus / cell surface / plasma membrane Similarity search - Function | ||||||||||||
Biological species | Mus musculus (house mouse) | ||||||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.65 Å | ||||||||||||
Authors | Lopez-Sagaseta, J. / Erausquin, E. | ||||||||||||
Funding support | Spain, 3items
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Citation | Journal: Front Immunol / Year: 2022 Title: Structural plasticity in I-A g7 links autoreactivity to hybrid insulin peptides in type I diabetes. Authors: Erausquin, E. / Serra, P. / Parras, D. / Santamaria, P. / Lopez-Sagaseta, J. | ||||||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7z50.cif.gz | 771.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7z50.ent.gz | 526 KB | Display | PDB format |
PDBx/mmJSON format | 7z50.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 7z50_validation.pdf.gz | 549.6 KB | Display | wwPDB validaton report |
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Full document | 7z50_full_validation.pdf.gz | 571.1 KB | Display | |
Data in XML | 7z50_validation.xml.gz | 59.1 KB | Display | |
Data in CIF | 7z50_validation.cif.gz | 81.4 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/z5/7z50 ftp://data.pdbj.org/pub/pdb/validation_reports/z5/7z50 | HTTPS FTP |
-Related structure data
Related structure data | 7qhpSC S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Components on special symmetry positions |
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Noncrystallographic symmetry (NCS) | NCS domain:
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