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Structure paper

TitleStructural plasticity in I-A g7 links autoreactivity to hybrid insulin peptides in type I diabetes.
Journal, issue, pagesFront Immunol, Vol. 13, Page 924311-924311, Year 2022
Publish dateDec 13, 2021 (structure data deposition date)
AuthorsErausquin, E. / Serra, P. / Parras, D. / Santamaria, P. / Lopez-Sagaseta, J.
External linksFront Immunol / PubMed:35967292
MethodsX-ray diffraction
Resolution1.82 - 2.65 Å
Structure data

PDB-7qhp:
Structure of I-Ag7 with a bound hybrid insulin peptide
Method: X-RAY DIFFRACTION / Resolution: 1.82 Å

PDB-7z50:
Structure of the highly diabetogenic 4.1-T cell receptor targeting a hybrid insulin peptide bound to I-Ag7.
Method: X-RAY DIFFRACTION / Resolution: 2.65 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-CL:
Unknown entry

Source
  • mus musculus (house mouse)
KeywordsIMMUNE SYSTEM / Diabetes / MHC class II / hybrid insulin peptide / autoimmune disease / T cell receptor / murine MHC class II

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