登録情報 | データベース: PDB / ID: 7z0g |
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タイトル | CPAP:TUBULIN:IE5 ALPHAREP COMPLEX P1 SPACE GROUP |
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要素 | - Centromere protein J
- IE5 ALPHAREP
- Tubulin alpha chain
- Tubulin beta chain
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キーワード | CELL CYCLE / MICROTUBULE / VINCA DOMAIN INHIBITORS / CENTRIOLE |
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機能・相同性 | 機能・相同性情報
astral microtubule nucleation / centriole elongation / gamma-tubulin small complex / positive regulation of centriole elongation / positive regulation of non-motile cilium assembly / positive regulation of establishment of protein localization / regulation of centriole replication / procentriole replication complex / positive regulation of centriole replication / motile cilium assembly ...astral microtubule nucleation / centriole elongation / gamma-tubulin small complex / positive regulation of centriole elongation / positive regulation of non-motile cilium assembly / positive regulation of establishment of protein localization / regulation of centriole replication / procentriole replication complex / positive regulation of centriole replication / motile cilium assembly / centriole replication / positive regulation of spindle assembly / microtubule nucleation / non-motile cilium assembly / gamma-tubulin binding / TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain / smoothened signaling pathway / positive regulation of G1/S transition of mitotic cell cycle / microtubule polymerization / microtubule-based process / cilium assembly / regulation of mitotic spindle organization / Loss of Nlp from mitotic centrosomes / Loss of proteins required for interphase microtubule organization from the centrosome / Recruitment of mitotic centrosome proteins and complexes / Recruitment of NuMA to mitotic centrosomes / Anchoring of the basal body to the plasma membrane / centriole / tubulin binding / AURKA Activation by TPX2 / ciliary basal body / positive regulation of receptor signaling pathway via JAK-STAT / structural constituent of cytoskeleton / Regulation of PLK1 Activity at G2/M Transition / transcription coactivator activity / microtubule / protein domain specific binding / cell division / centrosome / GTP binding / protein kinase binding / identical protein binding / cytoplasm / cytosol類似検索 - 分子機能 T-complex protein 10, C-terminal domain / T-complex protein 10 family / T-complex protein 10 C-terminus / : / Alpha tubulin / Tubulin-beta mRNA autoregulation signal. / Beta tubulin, autoregulation binding site / Beta tubulin / Tubulin / Tubulin, C-terminal ...T-complex protein 10, C-terminal domain / T-complex protein 10 family / T-complex protein 10 C-terminus / : / Alpha tubulin / Tubulin-beta mRNA autoregulation signal. / Beta tubulin, autoregulation binding site / Beta tubulin / Tubulin / Tubulin, C-terminal / Tubulin C-terminal domain / Tubulin, conserved site / Tubulin subunits alpha, beta, and gamma signature. / Tubulin/FtsZ family, C-terminal domain / Tubulin/FtsZ-like, C-terminal domain / Tubulin/FtsZ, C-terminal / Tubulin/FtsZ, 2-layer sandwich domain / Tubulin/FtsZ family, GTPase domain / Tubulin/FtsZ family, GTPase domain / Tubulin/FtsZ, GTPase domain / Tubulin/FtsZ, GTPase domain superfamily類似検索 - ドメイン・相同性 GUANOSINE-5'-DIPHOSPHATE / GUANOSINE-5'-TRIPHOSPHATE / Tubulin beta chain / Tubulin alpha chain / Centromere protein J類似検索 - 構成要素 |
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生物種 | synthetic construct (人工物)
Homo sapiens (ヒト)
![](img/tx_mammal.gif) Ovis aries (ヒツジ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.487 Å |
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データ登録者 | Gigant, B. / Campanacci, V. |
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資金援助 | フランス, 1件 組織 | 認可番号 | 国 |
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Fondation ARC | | フランス |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2022 タイトル: Structural convergence for tubulin binding of CPAP and vinca domain microtubule inhibitors. 著者: Campanacci, V. / Urvoas, A. / Ammar Khodja, L. / Aumont-Nicaise, M. / Noiray, M. / Lachkar, S. / Curmi, P.A. / Minard, P. / Gigant, B. |
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履歴 | 登録 | 2022年2月22日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2022年4月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年5月18日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID |
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改定 1.2 | 2024年1月31日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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