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Structure paper

TitleStructural convergence for tubulin binding of CPAP and vinca domain microtubule inhibitors.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 119, Page e2120098119-e2120098119, Year 2022
Publish dateOct 19, 2021 (structure data deposition date)
AuthorsCampanacci, V. / Urvoas, A. / Ammar Khodja, L. / Aumont-Nicaise, M. / Noiray, M. / Lachkar, S. / Curmi, P.A. / Minard, P. / Gigant, B.
External linksProc. Natl. Acad. Sci. USA / PubMed:35507869
MethodsX-ray diffraction
Resolution2.347 - 3.487 Å
Structure data

PDB-7q1e:
CPAP:TUBULIN:IIH5 ALPHAREP COMPLEX
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-7q1f:
CPAP:TUBULIN:IE5 ALPHAREP COMPLEX
Method: X-RAY DIFFRACTION / Resolution: 2.347 Å

PDB-7z0f:
CPAP:S-TUBULIN:IIH5 ALPHAREP COMPLEX
Method: X-RAY DIFFRACTION / Resolution: 2.396 Å

PDB-7z0g:
CPAP:TUBULIN:IE5 ALPHAREP COMPLEX P1 SPACE GROUP
Method: X-RAY DIFFRACTION / Resolution: 3.487 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-GDP:
GUANOSINE-5'-DIPHOSPHATE / GDP, energy-carrying molecule*YM

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

ChemComp-FLC:
CITRATE ANION

Source
  • synthetic construct (others)
  • homo sapiens (human)
  • ovis aries (sheep)
KeywordsCELL CYCLE / MICROTUBULE / CENTROMERE PROTEIN J / CENTRIOLE / VINCA DOMAIN INHIBITORS

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