登録情報 データベース : PDB / ID : 7yzd 構造の表示 ダウンロードとリンクタイトル Crystal structure of the zebrafish FoxH1 bound to the TGTTTACT site (fkh motif GTAAACA) 要素DNA (5'-D(*TP*CP*TP*CP*AP*GP*TP*AP*AP*AP*CP*AP*AP*TP*CP*T)-3')DNA (5'-D(P*AP*GP*AP*TP*TP*GP*TP*TP*TP*AP*CP*TP*GP*AP*GP*A)-3')Forkhead box protein H1 詳細キーワード DNA BINDING PROTEIN / transcription factor機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
prechordal plate formation / axial mesoderm morphogenesis / specification of animal organ position / axial mesodermal cell fate specification / floor plate formation / lens placode formation involved in camera-type eye formation / Spemann organizer formation at the embryonic shield / floor plate development / somite rostral/caudal axis specification / embryonic heart tube left/right pattern formation ... prechordal plate formation / axial mesoderm morphogenesis / specification of animal organ position / axial mesodermal cell fate specification / floor plate formation / lens placode formation involved in camera-type eye formation / Spemann organizer formation at the embryonic shield / floor plate development / somite rostral/caudal axis specification / embryonic heart tube left/right pattern formation / mesendoderm development / cell migration involved in gastrulation / endoderm formation / regulation of BMP signaling pathway / notochord formation / notochord development / embryonic heart tube morphogenesis / brain morphogenesis / dorsal/ventral pattern formation / determination of left/right symmetry / hypothalamus development / blood vessel development / heart looping / SMAD binding / cellular response to cytokine stimulus / mesoderm formation / anatomical structure morphogenesis / RNA polymerase II transcription regulatory region sequence-specific DNA binding / DNA-binding transcription repressor activity, RNA polymerase II-specific / regulation of gene expression / transcription regulator complex / sequence-specific DNA binding / cell differentiation / DNA-binding transcription factor activity, RNA polymerase II-specific / transcription cis-regulatory region binding / RNA polymerase II cis-regulatory region sequence-specific DNA binding / chromatin / regulation of transcription by RNA polymerase II / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / nucleus 類似検索 - 分子機能 : / : / Fork head domain / Forkhead domain / Fork head domain profile. / FORKHEAD / Fork head domain conserved site 2 / Fork head domain signature 2. / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily 類似検索 - ドメイン・相同性 ACETATE ION / TRIETHYLENE GLYCOL / DNA / DNA (> 10) / Forkhead box protein H1 類似検索 - 構成要素生物種 Danio rerio (ゼブラフィッシュ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.13 Å 詳細データ登録者 Pluta, R. / Macias, M.J. 資金援助 スペイン, European Union, 2件 詳細 詳細を隠す組織 認可番号 国 Ministry of Economy and Competitiveness (MINECO) BFU2017-82675-P スペイン H2020 Marie Curie Actions of the European Commission 754510 European Union
引用ジャーナル : Nat Commun / 年 : 2022タイトル : Molecular basis for DNA recognition by the maternal pioneer transcription factor FoxH1.著者 : Pluta, R. / Aragon, E. / Prescott, N.A. / Ruiz, L. / Mees, R.A. / Baginski, B. / Flood, J.R. / Martin-Malpartida, P. / Massague, J. / David, Y. / Macias, M.J. 履歴 登録 2022年2月19日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2022年11月16日 Provider : repository / タイプ : Initial release改定 1.1 2022年12月7日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title 改定 1.2 2024年1月31日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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