登録情報 データベース : PDB / ID : 7yyk 構造の表示 ダウンロードとリンクタイトル Crystal structure of the O-fucosylated form of TSRs1-3 from the human thrombospondin 1 要素Thrombospondin-1 詳細 キーワード CELL ADHESION / O-fucosylation / PoFUT2 / thrombospondin 1 / TSRs機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II / collagen V binding / negative regulation of dendritic cell antigen processing and presentation / negative regulation of nitric oxide mediated signal transduction / negative regulation of sprouting angiogenesis / chronic inflammatory response / negative regulation of endothelial cell chemotaxis / positive regulation of extrinsic apoptotic signaling pathway via death domain receptors / Defective B3GALTL causes PpS / O-glycosylation of TSR domain-containing proteins ... negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II / collagen V binding / negative regulation of dendritic cell antigen processing and presentation / negative regulation of nitric oxide mediated signal transduction / negative regulation of sprouting angiogenesis / chronic inflammatory response / negative regulation of endothelial cell chemotaxis / positive regulation of extrinsic apoptotic signaling pathway via death domain receptors / Defective B3GALTL causes PpS / O-glycosylation of TSR domain-containing proteins / negative regulation of fibroblast growth factor receptor signaling pathway / negative regulation of long-chain fatty acid import across plasma membrane / negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / positive regulation of transforming growth factor beta1 production / engulfment of apoptotic cell / negative regulation of focal adhesion assembly / low-density lipoprotein particle binding / fibrinogen complex / peptide cross-linking / fibrinogen binding / Signaling by PDGF / positive regulation of chemotaxis / platelet alpha granule / negative regulation of interleukin-12 production / positive regulation of endothelial cell apoptotic process / negative regulation of cell migration involved in sprouting angiogenesis / negative regulation of plasminogen activation / transforming growth factor beta binding / positive regulation of macrophage activation / positive regulation of fibroblast migration / sprouting angiogenesis / proteoglycan binding / negative regulation of endothelial cell migration / extracellular matrix structural constituent / Syndecan interactions / endopeptidase inhibitor activity / negative regulation of cell-matrix adhesion / negative regulation of cGMP-mediated signaling / positive regulation of macrophage chemotaxis / response to testosterone / fibroblast growth factor binding / phosphatidylserine binding / positive regulation of transforming growth factor beta receptor signaling pathway / behavioral response to pain / negative regulation of endothelial cell proliferation / response to magnesium ion / fibronectin binding / negative regulation of blood vessel endothelial cell migration / response to unfolded protein / positive regulation of blood vessel endothelial cell migration / Integrin cell surface interactions / positive regulation of blood coagulation / negative regulation of fibrinolysis / response to glucose / response to mechanical stimulus / positive regulation of phosphorylation / laminin binding / nitric oxide-cGMP-mediated signaling / positive regulation of endothelial cell migration / response to endoplasmic reticulum stress / negative regulation of angiogenesis / extracellular matrix / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / platelet alpha granule lumen / sarcoplasmic reticulum / secretory granule / response to progesterone / positive regulation of translation / negative regulation of extrinsic apoptotic signaling pathway / positive regulation of smooth muscle cell proliferation / positive regulation of MAP kinase activity / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / cellular response to growth factor stimulus / response to calcium ion / positive regulation of angiogenesis / positive regulation of reactive oxygen species metabolic process / positive regulation of tumor necrosis factor production / integrin binding / cell migration / Platelet degranulation / cellular response to tumor necrosis factor / heparin binding / cellular response to heat / protease binding / collagen-containing extracellular matrix / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / response to hypoxia / cell adhesion / positive regulation of cell migration / response to xenobiotic stimulus / inflammatory response / immune response / negative regulation of cell population proliferation / endoplasmic reticulum lumen / external side of plasma membrane / calcium ion binding / positive regulation of cell population proliferation / negative regulation of apoptotic process / apoptotic process / cell surface 類似検索 - 分子機能 Thrombospondin, C-terminal / Thrombospondin, type 3 repeat / Thrombospondin C-terminal region / Thrombospondin type-3 (TSP3) repeat profile. / Thrombospondin C-terminal domain profile. / Thrombospondin, type 3-like repeat / Thrombospondin type 3 repeat / TSP type-3 repeat / : / Thrombospondin N-terminal -like domains. ... Thrombospondin, C-terminal / Thrombospondin, type 3 repeat / Thrombospondin C-terminal region / Thrombospondin type-3 (TSP3) repeat profile. / Thrombospondin C-terminal domain profile. / Thrombospondin, type 3-like repeat / Thrombospondin type 3 repeat / TSP type-3 repeat / : / Thrombospondin N-terminal -like domains. / EGF domain / EGF domain / von Willebrand factor type C domain / VWFC domain signature. / VWFC domain profile. / von Willebrand factor (vWF) type C domain / VWFC domain / Thrombospondin type 1 domain / Thrombospondin type-1 (TSP1) repeat superfamily / Thrombospondin type-1 (TSP1) repeat profile. / Thrombospondin type 1 repeats / Thrombospondin type-1 (TSP1) repeat / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Epidermal growth factor-like domain. / EGF-like domain profile. / EGF-like domain signature 2. / EGF-like domain / Concanavalin A-like lectin/glucanase domain superfamily 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.6 Å 詳細データ登録者 Berardinelli, S.J. / Eletsky, A. / Valero-Gonzalez, J. / Ito, A. / Manjunath, R. / Hurtado-Guerrero, R. / Prestegard, J.R. / Woods, R.J. / Haltiwanger, R.S. 資金援助 スペイン, 1件 詳細 詳細を隠す組織 認可番号 国 Spanish Ministry of Economy and Competitiveness スペイン
引用ジャーナル : J.Biol.Chem. / 年 : 2022タイトル : O-fucosylation stabilizes the TSR3 motif in thrombospondin-1 by interacting with nearby amino acids and protecting a disulfide bond.著者 : Berardinelli, S.J. / Eletsky, A. / Valero-Gonzalez, J. / Ito, A. / Manjunath, R. / Hurtado-Guerrero, R. / Prestegard, J.H. / Woods, R.J. / Haltiwanger, R.S. 履歴 登録 2022年2月18日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2022年5月25日 Provider : repository / タイプ : Initial release改定 1.1 2022年6月1日 Group : Database references / カテゴリ : citationItem : _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title改定 1.2 2022年7月6日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation.title / _citation_author.name改定 1.3 2024年1月31日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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