登録情報 データベース : PDB / ID : 7yl2 構造の表示 ダウンロードとリンクタイトル Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor Y07004 要素Bromodomain-containing protein 4 詳細 キーワード ANTITUMOR PROTEIN / BRD4(1) / Bromodomain / Inhibitor機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II ... RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / chromosome / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / DNA damage response / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus 類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. ... Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily 類似検索 - ドメイン・相同性 Chem-JCO / NITRATE ION / Bromodomain-containing protein 4 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.62 Å 詳細データ登録者 Huang, Y. / Wei, A. / Dong, R. / Xu, H. / Zhang, C. / Chen, Z. / Li, J. / Wu, X. / Zhang, Y. / Xu, Y. 資金援助 中国, 1件 詳細 詳細を隠す組織 認可番号 国 National Natural Science Foundation of China (NSFC) 81673357 中国
引用ジャーナル : To Be Published タイトル : Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor Y07004著者 : Huang, Y. / Wei, A. / Dong, R. / Xu, H. / Zhang, C. / Chen, Z. / Li, J. / Wu, X. / Zhang, Y. / Xu, Y. 履歴 登録 2022年7月25日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2023年7月26日 Provider : repository / タイプ : Initial release改定 1.1 2024年5月29日 Group : Data collection / カテゴリ : chem_comp_atom / chem_comp_bond
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