登録情報 | データベース: PDB / ID: 7xe1 |
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タイトル | Crystal structure of LSD2 in complex with cis-4-Br-PCPA |
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要素 | Lysine-specific histone demethylase 1B |
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キーワード | OXIDOREDUCTASE / DEMETHYLASE / AMINE OXIDASE / CHROMATIN / HISTONE / FAD / MECHANISM-BASED INHIBITOR |
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機能・相同性 | 機能・相同性情報
epigenetic programing of female pronucleus / [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase / FAD-dependent H3K4me/H3K4me3 demethylase activity / genomic imprinting / histone demethylase activity / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / FAD binding / transcription initiation-coupled chromatin remodeling / HDMs demethylate histones / UCH proteinases ...epigenetic programing of female pronucleus / [histone H3]-N6,N6-dimethyl-L-lysine4 FAD-dependent demethylase / FAD-dependent H3K4me/H3K4me3 demethylase activity / genomic imprinting / histone demethylase activity / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / FAD binding / transcription initiation-coupled chromatin remodeling / HDMs demethylate histones / UCH proteinases / nucleosome / histone binding / oxidoreductase activity / chromatin / zinc ion binding / nucleoplasm / nucleus類似検索 - 分子機能 Zinc finger, CW-type / CW-type Zinc Finger / Zinc finger CW-type profile. / SWIRM domain / SWIRM domain / SWIRM domain profile. / : / Amine oxidase / Flavin containing amine oxidoreductase / Homeobox-like domain superfamily ...Zinc finger, CW-type / CW-type Zinc Finger / Zinc finger CW-type profile. / SWIRM domain / SWIRM domain / SWIRM domain profile. / : / Amine oxidase / Flavin containing amine oxidoreductase / Homeobox-like domain superfamily / FAD/NAD(P)-binding domain superfamily / Winged helix-like DNA-binding domain superfamily類似検索 - ドメイン・相同性 3-(4-bromophenyl)propanal / FLAVIN-ADENINE DINUCLEOTIDE / CITRATE ANION / DI(HYDROXYETHYL)ETHER / TRIETHYLENE GLYCOL / Lysine-specific histone demethylase 2類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.07 Å |
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データ登録者 | Niwa, H. / Sato, S. / Umehara, T. |
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資金援助 | 日本, 1件 組織 | 認可番号 | 国 |
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Japan Society for the Promotion of Science (JSPS) | 21K06461, 20H03388, 20K21406 | 日本 |
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引用 | ジャーナル: Acs Med.Chem.Lett. / 年: 2022 タイトル: Structure-Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2 著者: Niwa, H. / Watanabe, C. / Sato, S. / Harada, T. / Watanabe, H. / Tabusa, R. / Fukasawa, S. / Shiobara, A. / Hashimoto, T. / Ohno, O. / Nakamura, K. / Tsuganezawa, K. / Tanaka, A. / Shirouzu, ...著者: Niwa, H. / Watanabe, C. / Sato, S. / Harada, T. / Watanabe, H. / Tabusa, R. / Fukasawa, S. / Shiobara, A. / Hashimoto, T. / Ohno, O. / Nakamura, K. / Tsuganezawa, K. / Tanaka, A. / Shirouzu, M. / Honma, T. / Matsuno, K. / Umehara, T. |
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履歴 | 登録 | 2022年3月29日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2022年9月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年9月21日 | Group: Database references / Structure summary / カテゴリ: citation / struct Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _struct.title |
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改定 1.2 | 2023年11月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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