Entry Database : PDB / ID : 7x3z Structure visualization Downloads & linksTitle Crystal structure of human 17beta-hydroxysteroid dehydrogenase type 1 complexed with estrone and NAD Components17-beta-hydroxysteroid dehydrogenase type 1 Details Keywords OXIDOREDUCTASE / 17BETA-HSD1 / ESTRONE / FUNCTIONAL ANALYSES / STEROID / NAD/NADHFunction / homology Function and homology informationFunction Domain/homology Component
estradiol binding / 3(or 17)beta-hydroxysteroid dehydrogenase / 17-beta-hydroxysteroid dehydrogenase (NADP+) activity / estrogen biosynthetic process / testosterone dehydrogenase [NAD(P)+] activity / cellular response to metal ion / Estrogen biosynthesis / dihydrotestosterone 17-beta-dehydrogenase activity / testosterone biosynthetic process / testosterone dehydrogenase (NAD+) activity ... estradiol binding / 3(or 17)beta-hydroxysteroid dehydrogenase / 17-beta-hydroxysteroid dehydrogenase (NADP+) activity / estrogen biosynthetic process / testosterone dehydrogenase [NAD(P)+] activity / cellular response to metal ion / Estrogen biosynthesis / dihydrotestosterone 17-beta-dehydrogenase activity / testosterone biosynthetic process / testosterone dehydrogenase (NAD+) activity / testosterone 17-beta-dehydrogenase (NADP+) activity / 17beta-estradiol 17-dehydrogenase / estradiol 17-beta-dehydrogenase [NAD(P)+] activity / steroid biosynthetic process / estrogen metabolic process / NADP+ binding / lysosome organization / The canonical retinoid cycle in rods (twilight vision) / small molecule binding / catalytic activity / adipose tissue development / skeletal muscle tissue development / steroid binding / bone development / NADP binding / gene expression / protein homodimerization activity / cytosol / cytoplasm Similarity search - Function 17beta-dehydrogenase / short chain dehydrogenase / Short-chain dehydrogenase/reductase, conserved site / Short-chain dehydrogenases/reductases family signature. / Short-chain dehydrogenase/reductase SDR / NAD(P)-binding domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 2.25 Å DetailsModel details 17beta-HSD1-E1 complex Authors Li, T. / Lin, S.X. / Yin, H. Funding support 1items Details Hide detailsOrganization Grant number Country Other government
CitationJournal : J.Steroid Biochem.Mol.Biol. / Year : 2023Title : New insights into the substrate inhibition of human 17 beta-hydroxysteroid dehydrogenase type 1.Authors : Li, T. / Song, X. / Stephen, P. / Yin, H. / Lin, S.X. History Deposition Mar 1, 2022 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jan 25, 2023 Provider : repository / Type : Initial releaseRevision 1.1 May 29, 2024 Group : Data collection / Category : chem_comp_atom / chem_comp_bond
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