登録情報 | データベース: PDB / ID: 7wr6 |
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タイトル | Crystal structure of ADP-riboxanated caspase-4 in complex with Af1521 |
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要素 | - ADP-ribose glycohydrolase AF_1521
- Caspase-4
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キーワード | HYDROLASE / ADP-riboxanation |
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機能・相同性 | 機能・相同性情報
caspase-4 / non-canonical inflammasome complex / ADP-ribosylglutamate hydrolase activity / positive regulation of interleukin-18-mediated signaling pathway / peptidyl-glutamate ADP-deribosylation / non-canonical inflammasome complex assembly / AIM2 inflammasome complex / IPAF inflammasome complex / NLRP1 inflammasome complex / NLRP3 inflammasome complex ...caspase-4 / non-canonical inflammasome complex / ADP-ribosylglutamate hydrolase activity / positive regulation of interleukin-18-mediated signaling pathway / peptidyl-glutamate ADP-deribosylation / non-canonical inflammasome complex assembly / AIM2 inflammasome complex / IPAF inflammasome complex / NLRP1 inflammasome complex / NLRP3 inflammasome complex / CARD domain binding / caspase binding / positive regulation of tumor necrosis factor-mediated signaling pathway / 加水分解酵素; 糖加水分解酵素; N-グリコシル化合物加水分解酵素 / pyroptotic inflammatory response / protein autoprocessing / protein maturation / intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress / Pyroptosis / intrinsic apoptotic signaling pathway / lipopolysaccharide binding / NOD1/2 Signaling Pathway / positive regulation of inflammatory response / cellular response to amyloid-beta / positive regulation of neuron apoptotic process / regulation of inflammatory response / defense response to Gram-positive bacterium / defense response to bacterium / inflammatory response / cysteine-type endopeptidase activity / innate immune response / lipid binding / apoptotic process / endoplasmic reticulum membrane / endoplasmic reticulum / protein-containing complex / mitochondrion / proteolysis / extracellular region / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Caspase recruitment domain / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 / Peptidase family C14A, cysteine active site / Caspase family cysteine active site. / Caspase family p10 domain profile. ...Caspase recruitment domain / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / Peptidase family C14A, His active site / Caspase family histidine active site. / Peptidase C14, caspase non-catalytic subunit p10 / Peptidase family C14A, cysteine active site / Caspase family cysteine active site. / Caspase family p10 domain profile. / Peptidase C14A, caspase catalytic domain / Caspase, interleukin-1 beta converting enzyme (ICE) homologues / Peptidase C14, p20 domain / Caspase family p20 domain profile. / : / Caspase domain / Caspase-like domain superfamily / Death-like domain superfamily / Macro domain / Appr-1"-p processing enzyme / Macro domain / Macro domain profile. / Macro domain-like類似検索 - ドメイン・相同性 Chem-5ZY / ADP-ribose glycohydrolase AF_1521 / Caspase-4類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト)
![](img/tx_archaea.gif) Archaeoglobus fulgidus (古細菌) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.96 Å |
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データ登録者 | Hou, Y.J. / Zeng, H. / Shao, F. / Ding, J. |
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資金援助 | 中国, 1件 組織 | 認可番号 | 国 |
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Chinese Academy of Sciences | | 中国 |
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引用 | ジャーナル: Nat.Struct.Mol.Biol. / 年: 2023 タイトル: Structural mechanisms of calmodulin activation of Shigella effector OspC3 to ADP-riboxanate caspase-4/11 and block pyroptosis. 著者: Hou, Y. / Zeng, H. / Li, Z. / Feng, N. / Meng, F. / Xu, Y. / Li, L. / Shao, F. / Ding, J. |
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履歴 | 登録 | 2022年1月26日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2023年1月25日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年2月1日 | Group: Database references / カテゴリ: citation / Item: _citation.pdbx_database_id_PubMed / _citation.title |
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改定 1.2 | 2023年3月29日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.3 | 2023年11月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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