+Open data
-Basic information
Entry | Database: PDB / ID: 7wnh | ||||||
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Title | Crystal structure of Nurr1 binding to NBRE | ||||||
Components |
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Keywords | TRANSCRIPTION / Nurr1 / NBRE / DBD / LBD | ||||||
Function / homology | Function and homology information general adaptation syndrome / habenula development / cellular response to corticotropin-releasing hormone stimulus / central nervous system neuron differentiation / central nervous system projection neuron axonogenesis / : / regulation of dopamine metabolic process / nuclear glucocorticoid receptor binding / midbrain dopaminergic neuron differentiation / regulation of respiratory gaseous exchange ...general adaptation syndrome / habenula development / cellular response to corticotropin-releasing hormone stimulus / central nervous system neuron differentiation / central nervous system projection neuron axonogenesis / : / regulation of dopamine metabolic process / nuclear glucocorticoid receptor binding / midbrain dopaminergic neuron differentiation / regulation of respiratory gaseous exchange / dopaminergic neuron differentiation / neuron maturation / dopamine biosynthetic process / fat cell differentiation / nuclear retinoid X receptor binding / negative regulation of apoptotic signaling pathway / canonical Wnt signaling pathway / response to amphetamine / adult locomotory behavior / post-embryonic development / SUMOylation of intracellular receptors / neuron migration / Nuclear Receptor transcription pathway / nuclear receptor activity / beta-catenin binding / sequence-specific double-stranded DNA binding / cellular response to oxidative stress / DNA-binding transcription activator activity, RNA polymerase II-specific / transcription regulator complex / neuron apoptotic process / negative regulation of neuron apoptotic process / transcription by RNA polymerase II / DNA-binding transcription factor activity, RNA polymerase II-specific / response to hypoxia / nuclear speck / RNA polymerase II cis-regulatory region sequence-specific DNA binding / protein heterodimerization activity / DNA-templated transcription / regulation of transcription by RNA polymerase II / chromatin / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / protein-containing complex / DNA binding / zinc ion binding / nucleoplasm / nucleus / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) synthetic construct (others) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.1 Å | ||||||
Authors | Zhao, M. / Xu, T. / Wang, N. / Guo, Y. / Liu, J. | ||||||
Funding support | 1items
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Citation | Journal: Proc.Natl.Acad.Sci.USA / Year: 2022 Title: Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXR alpha heterodimer. Authors: Zhao, M. / Wang, N. / Guo, Y. / Li, J. / Yin, Y. / Dong, Y. / Zhu, J. / Peng, C. / Xu, T. / Liu, J. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7wnh.cif.gz | 330.3 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7wnh.ent.gz | 259.1 KB | Display | PDB format |
PDBx/mmJSON format | 7wnh.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 7wnh_validation.pdf.gz | 503.1 KB | Display | wwPDB validaton report |
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Full document | 7wnh_full_validation.pdf.gz | 522.1 KB | Display | |
Data in XML | 7wnh_validation.xml.gz | 46.8 KB | Display | |
Data in CIF | 7wnh_validation.cif.gz | 64.8 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/wn/7wnh ftp://data.pdbj.org/pub/pdb/validation_reports/wn/7wnh | HTTPS FTP |
-Related structure data
Related structure data | 1citS 1ovlS S: Starting model for refinement |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: _ / Refine code: _
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