- PDB-7v8q: Crystal structure of antibody 14A in complex with MUC1 Glycopepti... -
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基本情報
登録情報
データベース: PDB / ID: 7v8q
タイトル
Crystal structure of antibody 14A in complex with MUC1 Glycopeptide(GlycoT)
要素
14A fab heavy chain
14A fab light chain
Mucin-1 subunit alpha
キーワード
IMMUNE SYSTEM / Antibody / anti-MUC1 / Cancer / Glycopeptide / PEPTIDE BINDING PROTEIN
機能・相同性
機能・相同性情報
Defective GALNT3 causes HFTC / Defective C1GALT1C1 causes TNPS / Defective GALNT12 causes CRCS1 / Termination of O-glycan biosynthesis / O-linked glycosylation of mucins / negative regulation of cell adhesion mediated by integrin / negative regulation of transcription by competitive promoter binding / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / Dectin-2 family / DNA damage response, signal transduction by p53 class mediator ...Defective GALNT3 causes HFTC / Defective C1GALT1C1 causes TNPS / Defective GALNT12 causes CRCS1 / Termination of O-glycan biosynthesis / O-linked glycosylation of mucins / negative regulation of cell adhesion mediated by integrin / negative regulation of transcription by competitive promoter binding / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / Dectin-2 family / DNA damage response, signal transduction by p53 class mediator / DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest / transcription coregulator activity / Golgi lumen / p53 binding / Interleukin-4 and Interleukin-13 signaling / vesicle / apical plasma membrane / RNA polymerase II cis-regulatory region sequence-specific DNA binding / chromatin / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular exosome / nucleus / plasma membrane 類似検索 - 分子機能
National Natural Science Foundation of China (NSFC)
中国
引用
ジャーナル: To Be Published タイトル: Site-specific GalNAc modification on a MUC1 neoantigen epitope forms a basis for high-affinity antibody binding 著者: Han, Y.B. / Xu, L.
A: 14A fab light chain B: 14A fab heavy chain C: 14A fab light chain D: 14A fab heavy chain E: 14A fab light chain F: 14A fab heavy chain G: Mucin-1 subunit alpha H: Mucin-1 subunit alpha I: Mucin-1 subunit alpha ヘテロ分子