登録情報 | データベース: PDB / ID: 7v8f |
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タイトル | Crystal structure of UBE2L3 bound to HOIP RING1 domain. |
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要素 | - E3 ubiquitin-protein ligase RNF31
- Ubiquitin-conjugating enzyme E2 L3
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キーワード | LIGASE / E3 liagse / ubiquitin / innate immune |
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機能・相同性 | 機能・相同性情報
protein linear polyubiquitination / LUBAC complex / linear polyubiquitin binding / CD40 signaling pathway / cell cycle phase transition / RBR-type E3 ubiquitin transferase / ubiquitin-protein transferase activator activity / positive regulation of xenophagy / CD40 receptor complex / protein K11-linked ubiquitination ...protein linear polyubiquitination / LUBAC complex / linear polyubiquitin binding / CD40 signaling pathway / cell cycle phase transition / RBR-type E3 ubiquitin transferase / ubiquitin-protein transferase activator activity / positive regulation of xenophagy / CD40 receptor complex / protein K11-linked ubiquitination / negative regulation of necroptotic process / cellular response to glucocorticoid stimulus / K48-linked polyubiquitin modification-dependent protein binding / positive regulation of ubiquitin-protein transferase activity / TNFR1-induced proapoptotic signaling / positive regulation of protein targeting to mitochondrion / K63-linked polyubiquitin modification-dependent protein binding / E2 ubiquitin-conjugating enzyme / cellular response to steroid hormone stimulus / ubiquitin conjugating enzyme activity / ubiquitin ligase complex / Synthesis of active ubiquitin: roles of E1 and E2 enzymes / TNFR1-induced NF-kappa-B signaling pathway / ubiquitin binding / positive regulation of protein ubiquitination / Regulation of TNFR1 signaling / protein modification process / Regulation of necroptotic cell death / cytoplasmic side of plasma membrane / protein polyubiquitination / ubiquitin-protein transferase activity / ubiquitin protein ligase activity / Antigen processing: Ubiquitination & Proteasome degradation / presynapse / E3 ubiquitin ligases ubiquitinate target proteins / positive regulation of NF-kappaB transcription factor activity / T cell receptor signaling pathway / ubiquitin-dependent protein catabolic process / positive regulation of canonical NF-kappaB signal transduction / cell population proliferation / transcription coactivator activity / protein ubiquitination / defense response to bacterium / ubiquitin protein ligase binding / regulation of DNA-templated transcription / enzyme binding / RNA binding / zinc ion binding / nucleoplasm / ATP binding / identical protein binding / nucleus / cytoplasm / cytosol類似検索 - 分子機能 : / : / : / : / : / E3 ubiquitin-protein ligase RNF31-like / E3 ubiquitin-protein ligase RNF31, UBA-like domain / E3 ubiquitin-protein ligase RNF31, PUB domain / RNF31, C-terminal / HOIP UBA domain pair ...: / : / : / : / : / E3 ubiquitin-protein ligase RNF31-like / E3 ubiquitin-protein ligase RNF31, UBA-like domain / E3 ubiquitin-protein ligase RNF31, PUB domain / RNF31, C-terminal / HOIP UBA domain pair / E3 Ubiquitin Ligase RBR C-terminal domain / PNGase/UBA- or UBX-containing domain / PUB-like domain superfamily / PUB domain / PUB domain / IBR domain, a half RING-finger domain / IBR domain / In Between Ring fingers / TRIAD supradomain / TRIAD supradomain profile. / Zinc finger domain / Ubiquitin-associated domain / Ubiquitin-associated domain (UBA) profile. / Zinc finger RanBP2 type profile. / Zinc finger RanBP2-type signature. / Zinc finger, RanBP2-type superfamily / Zinc finger, RanBP2-type / Ubiquitin-conjugating enzyme, active site / Ubiquitin-conjugating (UBC) active site signature. / Ubiquitin-conjugating enzyme E2, catalytic domain homologues / Ubiquitin-conjugating enzyme E2 / Ubiquitin-conjugating enzyme / Ubiquitin-conjugating (UBC) core domain profile. / Ubiquitin-conjugating enzyme/RWD-like / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / Zinc finger, RING/FYVE/PHD-type類似検索 - ドメイン・相同性 Ubiquitin-conjugating enzyme E2 L3 / E3 ubiquitin-protein ligase RNF31類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.66 Å |
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データ登録者 | Liu, J. / Wang, Y. / Pan, L. |
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資金援助 | 中国, 5件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China (NSFC) | 32071297 | 中国 | National Natural Science Foundation of China (NSFC) | 21822705 | 中国 | National Natural Science Foundation of China (NSFC) | 91753113 | 中国 | National Natural Science Foundation of China (NSFC) | 21621002 | 中国 | National Natural Science Foundation of China (NSFC) | 32071219 | 中国 |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2022 タイトル: Mechanistic insights into the subversion of the linear ubiquitin chain assembly complex by the E3 ligase IpaH1.4 of Shigella flexneri. 著者: Liu, J. / Wang, Y. / Wang, D. / Wang, Y. / Xu, X. / Zhang, Y. / Li, Y. / Zhang, M. / Gong, X. / Tang, Y. / Shen, L. / Li, M. / Pan, L. |
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履歴 | 登録 | 2021年8月22日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2022年3月30日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年11月29日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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