PDB-7v7h: Cryo-EM structure of SARS-CoV-2 S-Kappa variant (B.1.617.1), dime...

基本情報

• 登録情報: データベース: PDB / ID: 7v7h
• タイトル: Cryo-EM structure of SARS-CoV-2 S-Kappa variant (B.1.617.1), dimer of S trimer conformation 1
• 要素: Spike glycoprotein
• キーワード: VIRAL PROTEIN / SARS-CoV-2 / Spike protein

機能・相同性

分子機能:

Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / entry receptor-mediated virion attachment to host cell / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / receptor-mediated endocytosis of virus by host cell / membrane fusion / Attachment and Entry / positive regulation of viral entry into host cell / receptor-mediated virion attachment to host cell / receptor ligand activity / host cell surface receptor binding / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / SARS-CoV-2 activates/modulates innate and adaptive immune responses / host cell plasma membrane / virion membrane / identical protein binding / membrane / plasma membrane

ドメイン・相同性:

Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like / Betacoronavirus-like spike glycoprotein S1, N-terminal / Spike glycoprotein S2, coronavirus, heptad repeat 1 / Spike glycoprotein S2, coronavirus, heptad repeat 2 / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile. / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile. / Spike glycoprotein S2 superfamily, coronavirus / Spike glycoprotein S2, coronavirus / Coronavirus spike glycoprotein S2 / Coronavirus spike glycoprotein S1, C-terminal / Coronavirus spike glycoprotein S1, C-terminal

構成要素:

Spike glycoprotein

• 生物種: Severe acute respiratory syndrome coronavirus 2 (ウイルス)
• 手法: 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.2 Å
• データ登録者: Yang, T.J. / Yu, P.Y. / Chang, Y.C. / Hsu, S.T.D.

資金援助

台湾, 4件

組織	認可番号	国
Ministry of Science and Technology (MoST, Taiwan)	109-3114-Y-001-001	台湾
Academia Sinica (Taiwan)	AS-CDA-109-L08	台湾
Academia Sinica (Taiwan)	AS-CFII-108-110	台湾
Academia Sinica (Taiwan)	AS-CFII108-111	台湾

• 引用: ジャーナル: To Be Published; タイトル: Cryo-EM structure of SARS-CoV-2 S-Kappa variant (B.1.617.1), dimer of S trimer conformation 1; 著者: Yang, T.J. / Yu, P.Y. / Chang, Y.C. / Hsu, S.T.D.

履歴

登録	2021年8月21日	登録サイト: PDBJ / 処理サイト: PDBJ
改定 1.0	2021年10月6日	Provider: repository / タイプ: Initial release

集合体

登録構造単位

A: Spike glycoprotein

B: Spike glycoprotein

C: Spike glycoprotein

D: Spike glycoprotein

E: Spike glycoprotein

F: Spike glycoprotein

ヘテロ分子

概要:

• 890 kDa, 6 ポリマー

構成要素の詳細:

	分子量 (理論値)	分子数
合計 (水以外)	890,437	102
ポリマ－	853,599	6
非ポリマー	36,839	96
水	0	0

1

概要:

• 登録構造と同一
• 登録者が定義した集合体
• 根拠: gel filtration

対称操作:

タイプ	名称	対称操作	数
identity operation	1_555		1

計算値:

Buried area	87600 Å2
ΔGint	182 kcal/mol
Surface area	311230 Å2

要素