Entry Database : PDB / ID : 7uc6 Structure visualization Downloads & linksTitle Stat5a Core in complex with Compound 12 ComponentsSignal transducer and activator of transcription 5A Details Keywords TRANSCRIPTION/INHIBITOR / STAT5a / ACTIVATOR / TRANSCRIPTION / TRANSCRIPTION-INHIBITOR COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of mast cell differentiation / development of secondary female sexual characteristics / development of secondary male sexual characteristics / eosinophil differentiation / positive regulation of natural killer cell differentiation / negative regulation of mast cell apoptotic process / taurine metabolic process / negative regulation of erythrocyte differentiation / luteinization / positive regulation of mast cell proliferation ... positive regulation of mast cell differentiation / development of secondary female sexual characteristics / development of secondary male sexual characteristics / eosinophil differentiation / positive regulation of natural killer cell differentiation / negative regulation of mast cell apoptotic process / taurine metabolic process / negative regulation of erythrocyte differentiation / luteinization / positive regulation of mast cell proliferation / mast cell differentiation / regulation of epithelial cell differentiation / mast cell apoptotic process / mast cell proliferation / negative regulation of T-helper 17 cell lineage commitment / natural killer cell differentiation / Interleukin-9 signaling / Interleukin-21 signaling / interleukin-7-mediated signaling pathway / interleukin-9-mediated signaling pathway / interleukin-4-mediated signaling pathway / positive regulation of natural killer cell mediated cytotoxicity / gamma-delta T cell differentiation / positive regulation of gamma-delta T cell differentiation / regulation of steroid metabolic process / interleukin-2-mediated signaling pathway / mammary gland epithelium development / STAT5 Activation / thrombopoietin-mediated signaling pathway / Peyer's patch development / Erythropoietin activates STAT5 / epithelial cell differentiation involved in prostate gland development / interleukin-5-mediated signaling pathway / reelin-mediated signaling pathway / prostate gland epithelium morphogenesis / lipid storage / interleukin-15-mediated signaling pathway / cellular response to granulocyte macrophage colony-stimulating factor stimulus / positive regulation of multicellular organism growth / activated T cell proliferation / Signaling by cytosolic FGFR1 fusion mutants / Interleukin-15 signaling / interleukin-3-mediated signaling pathway / Signaling by Leptin / Interleukin-2 signaling / positive regulation of B cell differentiation / Interleukin-20 family signaling / natural killer cell mediated cytotoxicity / STAT5 activation downstream of FLT3 ITD mutants / Prolactin receptor signaling / phosphate ion binding / positive regulation of activated T cell proliferation / T cell homeostasis / Interleukin-3, Interleukin-5 and GM-CSF signaling / regulation of multicellular organism growth / positive regulation of blood vessel endothelial cell migration / growth hormone receptor signaling pathway via JAK-STAT / cell surface receptor signaling pathway via JAK-STAT / Growth hormone receptor signaling / Nuclear signaling by ERBB4 / Nuclear events stimulated by ALK signaling in cancer / Signaling by CSF3 (G-CSF) / lactation / positive regulation of endothelial cell proliferation / Signaling by FLT3 fusion proteins / Interleukin-7 signaling / positive regulation of interleukin-2 production / Downstream signal transduction / positive regulation of mitotic cell cycle / B cell differentiation / Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants / erythrocyte differentiation / Inactivation of CSF3 (G-CSF) signaling / female pregnancy / Signaling by SCF-KIT / defense response / response to peptide hormone / RNA polymerase II transcription regulator complex / positive regulation of inflammatory response / cytokine-mediated signaling pathway / T cell differentiation in thymus / mitotic cell cycle / regulation of cell population proliferation / DNA-binding transcription activator activity, RNA polymerase II-specific / DNA-binding transcription factor binding / transcription by RNA polymerase II / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / regulation of transcription by RNA polymerase II / chromatin / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytosol / cytoplasm Similarity search - Function STAT5a/5b / : / STAT transcription factor, DNA-binding domain / STAT transcription factor, all-alpha domain / STAT transcription factor, DNA-binding, N-terminal / STAT transcription factor, protein interaction / STAT transcription factor, all-alpha domain / STAT transcription factor, DNA-binding / : / STAT transcription factor, coiled-coil domain ... STAT5a/5b / : / STAT transcription factor, DNA-binding domain / STAT transcription factor, all-alpha domain / STAT transcription factor, DNA-binding, N-terminal / STAT transcription factor, protein interaction / STAT transcription factor, all-alpha domain / STAT transcription factor, DNA-binding / : / STAT transcription factor, coiled-coil domain / STAT protein, DNA binding domain / STAT protein, protein interaction domain / Signal transducer and activator of transcription, linker domain / STAT protein, protein interaction domain / STAT transcription factor, N-terminal domain superfamily / Transcription factor STAT / STAT transcription factor, coiled coil / Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 / p53-like transcription factor, DNA-binding / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / SH2 domain superfamily / Up-down Bundle / Immunoglobulin-like / Sandwich / Mainly Beta / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.101 Å DetailsAuthors Meagher, J.L. / Stuckey, J.A. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Cancer Institute (NIH/NCI) 1-R01-CA244509 United States
CitationJournal : J.Med.Chem. / Year : 2023Title : Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia.Authors : Kaneshige, A. / Bai, L. / Wang, M. / McEachern, D. / Meagher, J.L. / Xu, R. / Kirchhoff, P.D. / Wen, B. / Sun, D. / Stuckey, J.A. / Wang, S. History Deposition Mar 16, 2022 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Feb 15, 2023 Provider : repository / Type : Initial releaseRevision 1.1 Mar 8, 2023 Group : Database references / Category : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID Revision 1.2 May 22, 2024 Group : Data collection / Category : chem_comp_atom / chem_comp_bond
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