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-Structure paper
Title | Discovery of a Potent and Selective STAT5 PROTAC Degrader with Strong Antitumor Activity In Vivo in Acute Myeloid Leukemia. |
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Journal, issue, pages | J. Med. Chem., Vol. 66, Page 2717-2743, Year 2023 |
Publish date | Mar 15, 2022 (structure data deposition date) |
![]() | Kaneshige, A. / Bai, L. / Wang, M. / McEachern, D. / Meagher, J.L. / Xu, R. / Kirchhoff, P.D. / Wen, B. / Sun, D. / Stuckey, J.A. / Wang, S. |
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Methods | X-ray diffraction |
Resolution | 2.352 - 3.102 Å |
Structure data | ![]() PDB-7ubt: ![]() PDB-7uc6: ![]() PDB-7uc7: |
Chemicals | ![]() ChemComp-GOL: ![]() ChemComp-MIW: ![]() ChemComp-HOH: ![]() ChemComp-MJ6: ![]() ChemComp-MQX: |
Source |
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![]() | TRANSCRIPTION/INHIBITOR / STAT5a / ACTIVATOR / TRANSCRIPTION / TRANSCRIPTION-INHIBITOR COMPLEX |