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Yorodumi- PDB-7u5p: CRYSTAL STRUCTURE OF THE ACTIVIN RECEPTOR TYPE-2A LIGAND BINDING ... -
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-Basic information
Entry | Database: PDB / ID: 7u5p | ||||||
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Title | CRYSTAL STRUCTURE OF THE ACTIVIN RECEPTOR TYPE-2A LIGAND BINDING DOMAIN IN COMPLEX WITH ACTIVIN-A | ||||||
Components |
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Keywords | SIGNALING PROTEIN / Cell Signaling / Receptor-ligand complex / Growth factor / Receptor interaction / Activin A / ActRIIa | ||||||
Function / homology | Function and homology information Regulation of signaling by NODAL / inhibin-betaglycan-ActRII complex / activin A complex / inhibin A complex / cardiac fibroblast cell development / negative regulation of B cell differentiation / regulation of follicle-stimulating hormone secretion / inhibin binding / positive regulation of ovulation / GABAergic neuron differentiation ...Regulation of signaling by NODAL / inhibin-betaglycan-ActRII complex / activin A complex / inhibin A complex / cardiac fibroblast cell development / negative regulation of B cell differentiation / regulation of follicle-stimulating hormone secretion / inhibin binding / positive regulation of ovulation / GABAergic neuron differentiation / Antagonism of Activin by Follistatin / negative regulation of follicle-stimulating hormone secretion / progesterone secretion / penile erection / type II activin receptor binding / striatal medium spiny neuron differentiation / positive regulation of activin receptor signaling pathway / Glycoprotein hormones / activin receptor activity / negative regulation of macrophage differentiation / cellular response to oxygen-glucose deprivation / positive regulation of follicle-stimulating hormone secretion / Sertoli cell proliferation / hemoglobin biosynthetic process / sperm ejaculation / BMP receptor activity / embryonic skeletal system development / activin receptor complex / cellular response to follicle-stimulating hormone stimulus / cellular response to cholesterol / receptor protein serine/threonine kinase / transmembrane receptor protein serine/threonine kinase activity / activin binding / Signaling by BMP / cellular response to BMP stimulus / activin receptor signaling pathway / negative regulation of phosphorylation / SMAD protein signal transduction / Signaling by Activin / mesodermal cell differentiation / positive regulation of extrinsic apoptotic signaling pathway in absence of ligand / Signaling by NODAL / gastrulation with mouth forming second / cellular response to angiotensin / regulation of nitric oxide biosynthetic process / determination of left/right symmetry / odontogenesis / positive regulation of transcription by RNA polymerase III / anterior/posterior pattern specification / cell surface receptor protein serine/threonine kinase signaling pathway / negative regulation of G1/S transition of mitotic cell cycle / response to aldosterone / roof of mouth development / eyelid development in camera-type eye / endodermal cell differentiation / growth factor binding / odontogenesis of dentin-containing tooth / mesoderm development / peptide hormone binding / positive regulation of SMAD protein signal transduction / negative regulation of type II interferon production / hair follicle development / positive regulation of collagen biosynthetic process / BMP signaling pathway / positive regulation of osteoblast differentiation / positive regulation of bone mineralization / hematopoietic progenitor cell differentiation / coreceptor activity / extrinsic apoptotic signaling pathway / ovarian follicle development / positive regulation of protein metabolic process / erythrocyte differentiation / positive regulation of erythrocyte differentiation / cytokine activity / PDZ domain binding / growth factor activity / hormone activity / negative regulation of cell growth / cellular response to growth factor stimulus / defense response / cytokine-mediated signaling pathway / autophagy / male gonad development / cell-cell signaling / nervous system development / cellular response to hypoxia / spermatogenesis / transcription by RNA polymerase II / positive regulation of ERK1 and ERK2 cascade / cell differentiation / cell surface receptor signaling pathway / receptor complex / positive regulation of protein phosphorylation / negative regulation of cell population proliferation / protein serine/threonine kinase activity / positive regulation of gene expression / protein-containing complex binding / regulation of transcription by RNA polymerase II / perinuclear region of cytoplasm / positive regulation of DNA-templated transcription Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 3.14 Å | ||||||
Authors | Chu, K.Y. / Malik, A. / Thamilselvan, V. / Martinez-Hackert, E. | ||||||
Funding support | United States, 1items
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Citation | Journal: J.Biol.Chem. / Year: 2022 Title: Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition. Authors: Chu, K.Y. / Malik, A. / Thamilselvan, V. / Martinez-Hackert, E. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7u5p.cif.gz | 331.9 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7u5p.ent.gz | 269.7 KB | Display | PDB format |
PDBx/mmJSON format | 7u5p.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/u5/7u5p ftp://data.pdbj.org/pub/pdb/validation_reports/u5/7u5p | HTTPS FTP |
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-Related structure data
Related structure data | 7u5oC 1s4yS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data | Similarity search - Function & homologyF&H Search |
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-Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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