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- PDB-7u5o: CRYSTAL STRUCTURE OF THE BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE... -
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Basic information
Entry | Database: PDB / ID: 7u5o | ||||||
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Title | CRYSTAL STRUCTURE OF THE BONE MORPHOGENETIC PROTEIN RECEPTOR TYPE 2 LIGAND BINDING DOMAIN IN COMPLEX WITH ACTIVIN-B | ||||||
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![]() | SIGNALING PROTEIN / Cell Signaling / Receptor-ligand complex / Growth factor / Receptor interaction / Activin B / BMPRII | ||||||
Function / homology | ![]() negative regulation of hepatocyte growth factor production / inhibin B complex / reproductive senescence / response to gonadotropin / semi-lunar valve development / : / inhibin binding / positive regulation of ovulation / activin receptor activity, type II / negative regulation of chondrocyte proliferation ...negative regulation of hepatocyte growth factor production / inhibin B complex / reproductive senescence / response to gonadotropin / semi-lunar valve development / : / inhibin binding / positive regulation of ovulation / activin receptor activity, type II / negative regulation of chondrocyte proliferation / Antagonism of Activin by Follistatin / negative regulation of follicle-stimulating hormone secretion / lymphatic endothelial cell differentiation / regulation of lung blood pressure / pulmonary valve development / response to insecticide / tricuspid valve morphogenesis / Glycoprotein hormones / chondrocyte development / negative regulation of cell proliferation involved in heart valve morphogenesis / venous blood vessel development / aortic valve development / positive regulation of follicle-stimulating hormone secretion / BMP binding / proteoglycan biosynthetic process / negative regulation of muscle cell differentiation / atrial septum morphogenesis / endocardial cushion development / maternal placenta development / positive regulation of cartilage development / endochondral bone morphogenesis / transforming growth factor beta receptor activity / pituitary gland development / lung vasculature development / lymphangiogenesis / mitral valve morphogenesis / retina vasculature development in camera-type eye / BMP receptor activity / positive regulation of axon extension involved in axon guidance / cellular response to cholesterol / artery development / receptor protein serine/threonine kinase / Signaling by BMP / cellular response to BMP stimulus / activin receptor signaling pathway / SMAD protein signal transduction / Signaling by Activin / oocyte development / endothelial cell apoptotic process / cellular response to leptin stimulus / positive regulation of ossification / negative regulation of systemic arterial blood pressure / cellular response to thyroid hormone stimulus / limb development / endothelial cell proliferation / anterior/posterior pattern specification / cell surface receptor protein serine/threonine kinase signaling pathway / negative regulation of vasoconstriction / ventricular septum morphogenesis / lung alveolus development / seminiferous tubule development / positive regulation of epithelial cell migration / blood vessel development / fat cell differentiation / outflow tract morphogenesis / growth factor binding / positive regulation of SMAD protein signal transduction / mesoderm formation / cellular response to Thyroglobulin triiodothyronine / blood vessel remodeling / cellular response to interleukin-1 / negative regulation of insulin secretion / BMP signaling pathway / positive regulation of bone mineralization / positive regulation of osteoblast differentiation / clathrin-coated pit / cellular response to cAMP / ovarian follicle development / cellular response to calcium ion / cellular response to starvation / protein tyrosine kinase binding / basal plasma membrane / cytokine activity / caveola / cell periphery / positive regulation of apoptotic signaling pathway / adherens junction / negative regulation of smooth muscle cell proliferation / growth factor activity / hormone activity / negative regulation of cell growth / cellular response to growth factor stimulus / defense response / response to wounding / osteoblast differentiation / cellular response to insulin stimulus / regulation of cell population proliferation / spermatogenesis / postsynaptic density / cell differentiation Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Chu, K.Y. / Malik, A. / Thamilselvan, V. / Martinez-Hackert, E. | ||||||
Funding support | ![]()
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![]() | ![]() Title: Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition. Authors: Chu, K.Y. / Malik, A. / Thamilselvan, V. / Martinez-Hackert, E. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 241.9 KB | Display | ![]() |
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PDB format | ![]() | 194.7 KB | Display | ![]() |
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-Validation report
Summary document | ![]() | 480 KB | Display | ![]() |
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Full document | ![]() | 487.7 KB | Display | |
Data in XML | ![]() | 21.1 KB | Display | |
Data in CIF | ![]() | 28.9 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 7u5pC ![]() 2hlrS S: Starting model for refinement C: citing same article ( |
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Similar structure data | Similarity search - Function & homology ![]() |
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Assembly
Deposited unit | ![]()
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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