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- PDB-7u5p: CRYSTAL STRUCTURE OF THE ACTIVIN RECEPTOR TYPE-2A LIGAND BINDING ... -
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Basic information
Entry | Database: PDB / ID: 7u5p | ||||||
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Title | CRYSTAL STRUCTURE OF THE ACTIVIN RECEPTOR TYPE-2A LIGAND BINDING DOMAIN IN COMPLEX WITH ACTIVIN-A | ||||||
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![]() | SIGNALING PROTEIN / Cell Signaling / Receptor-ligand complex / Growth factor / Receptor interaction / Activin A / ActRIIa | ||||||
Function / homology | ![]() Regulation of signaling by NODAL / inhibin-betaglycan-ActRII complex / activin A complex / inhibin A complex / cardiac fibroblast cell development / negative regulation of B cell differentiation / regulation of follicle-stimulating hormone secretion / inhibin binding / positive regulation of ovulation / GABAergic neuron differentiation ...Regulation of signaling by NODAL / inhibin-betaglycan-ActRII complex / activin A complex / inhibin A complex / cardiac fibroblast cell development / negative regulation of B cell differentiation / regulation of follicle-stimulating hormone secretion / inhibin binding / positive regulation of ovulation / GABAergic neuron differentiation / Antagonism of Activin by Follistatin / negative regulation of follicle-stimulating hormone secretion / progesterone secretion / penile erection / type II activin receptor binding / striatal medium spiny neuron differentiation / positive regulation of activin receptor signaling pathway / activin receptor activity / Glycoprotein hormones / negative regulation of macrophage differentiation / positive regulation of follicle-stimulating hormone secretion / cellular response to oxygen-glucose deprivation / Sertoli cell proliferation / hemoglobin biosynthetic process / sperm ejaculation / BMP receptor activity / embryonic skeletal system development / activin receptor complex / cellular response to follicle-stimulating hormone stimulus / cellular response to cholesterol / receptor protein serine/threonine kinase / transmembrane receptor protein serine/threonine kinase activity / Signaling by BMP / activin binding / cellular response to BMP stimulus / activin receptor signaling pathway / negative regulation of phosphorylation / SMAD protein signal transduction / Signaling by Activin / mesodermal cell differentiation / positive regulation of extrinsic apoptotic signaling pathway in absence of ligand / Signaling by NODAL / gastrulation with mouth forming second / cellular response to angiotensin / regulation of nitric oxide biosynthetic process / determination of left/right symmetry / odontogenesis / positive regulation of transcription by RNA polymerase III / anterior/posterior pattern specification / cell surface receptor protein serine/threonine kinase signaling pathway / negative regulation of G1/S transition of mitotic cell cycle / response to aldosterone / roof of mouth development / eyelid development in camera-type eye / endodermal cell differentiation / growth factor binding / odontogenesis of dentin-containing tooth / mesoderm development / peptide hormone binding / positive regulation of SMAD protein signal transduction / negative regulation of type II interferon production / hair follicle development / positive regulation of collagen biosynthetic process / BMP signaling pathway / positive regulation of bone mineralization / hematopoietic progenitor cell differentiation / positive regulation of osteoblast differentiation / coreceptor activity / extrinsic apoptotic signaling pathway / ovarian follicle development / positive regulation of protein metabolic process / erythrocyte differentiation / positive regulation of erythrocyte differentiation / cytokine activity / PDZ domain binding / growth factor activity / hormone activity / negative regulation of cell growth / cellular response to growth factor stimulus / defense response / autophagy / cytokine-mediated signaling pathway / : / male gonad development / cell-cell signaling / nervous system development / cellular response to hypoxia / spermatogenesis / transcription by RNA polymerase II / positive regulation of ERK1 and ERK2 cascade / cell surface receptor signaling pathway / cell differentiation / receptor complex / positive regulation of protein phosphorylation / phosphorylation / negative regulation of cell population proliferation / protein serine/threonine kinase activity / positive regulation of gene expression / protein-containing complex binding / regulation of transcription by RNA polymerase II Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() | ||||||
![]() | Chu, K.Y. / Malik, A. / Thamilselvan, V. / Martinez-Hackert, E. | ||||||
Funding support | ![]()
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![]() | ![]() Title: Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition. Authors: Chu, K.Y. / Malik, A. / Thamilselvan, V. / Martinez-Hackert, E. | ||||||
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Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 331.9 KB | Display | ![]() |
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-Validation report
Summary document | ![]() | 512.7 KB | Display | ![]() |
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Full document | ![]() | 520.9 KB | Display | |
Data in XML | ![]() | 28.2 KB | Display | |
Data in CIF | ![]() | 40.5 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 7u5oC ![]() 1s4yS S: Starting model for refinement C: citing same article ( |
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Similar structure data | Similarity search - Function & homology ![]() |
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Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
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