登録情報 | データベース: PDB / ID: 7tyg |
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タイトル | Structure of the human leucine rich repeat protein SHOC2, residues 80-582 |
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要素 | Leucine-rich repeat protein SHOC-2 |
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キーワード | HYDROLASE / RAS / PP1 / SHOC2 / LRR |
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機能・相同性 | 機能・相同性情報
cellular response to growth hormone stimulus / protein phosphatase type 1 complex / negative regulation of neural precursor cell proliferation / cyclic-GMP-AMP transmembrane import across plasma membrane / nerve growth factor signaling pathway / protein phosphatase regulator activity / protein phosphatase 1 binding / SHOC2 M1731 mutant abolishes MRAS complex function / Gain-of-function MRAS complexes activate RAF signaling / positive regulation of Ras protein signal transduction ...cellular response to growth hormone stimulus / protein phosphatase type 1 complex / negative regulation of neural precursor cell proliferation / cyclic-GMP-AMP transmembrane import across plasma membrane / nerve growth factor signaling pathway / protein phosphatase regulator activity / protein phosphatase 1 binding / SHOC2 M1731 mutant abolishes MRAS complex function / Gain-of-function MRAS complexes activate RAF signaling / positive regulation of Ras protein signal transduction / negative regulation of neuron differentiation / fibroblast growth factor receptor signaling pathway / positive regulation of neuron differentiation / RAF activation / positive regulation of neuron projection development / protein phosphatase binding / Ras protein signal transduction / signal transduction / nucleoplasm / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Leucine-rich repeats, bacterial type / Leucine-rich repeat, SDS22-like subfamily / Leucine rich repeat / Leucine-rich repeat, typical subtype / Leucine-rich repeats, typical (most populated) subfamily / Leucine-rich repeat profile. / Leucine-rich repeat / Leucine-rich repeat domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.9 Å |
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データ登録者 | Dhembi, A. / Clark, K. / King, D.A. |
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資金援助 | 1件 |
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引用 | ジャーナル: Nature / 年: 2022 タイトル: Structure of the MRAS-SHOC2-PP1C phosphatase complex. 著者: Hauseman, Z.J. / Fodor, M. / Dhembi, A. / Viscomi, J. / Egli, D. / Bleu, M. / Katz, S. / Park, E. / Jang, D.M. / Porter, K.A. / Meili, F. / Guo, H. / Kerr, G. / Molle, S. / Velez-Vega, C. / ...著者: Hauseman, Z.J. / Fodor, M. / Dhembi, A. / Viscomi, J. / Egli, D. / Bleu, M. / Katz, S. / Park, E. / Jang, D.M. / Porter, K.A. / Meili, F. / Guo, H. / Kerr, G. / Molle, S. / Velez-Vega, C. / Beyer, K.S. / Galli, G.G. / Maira, S.M. / Stams, T. / Clark, K. / Eck, M.J. / Tordella, L. / Thoma, C.R. / King, D.A. |
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履歴 | 登録 | 2022年2月13日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2022年6月22日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2022年8月17日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2022年9月21日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.3 | 2023年10月18日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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