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Structure paper

TitleStructure of the MRAS-SHOC2-PP1C phosphatase complex.
Journal, issue, pagesNature, Vol. 609, Page 416-423, Year 2022
Publish dateFeb 9, 2022 (structure data deposition date)
AuthorsHauseman, Z.J. / Fodor, M. / Dhembi, A. / Viscomi, J. / Egli, D. / Bleu, M. / Katz, S. / Park, E. / Jang, D.M. / Porter, K.A. ...Hauseman, Z.J. / Fodor, M. / Dhembi, A. / Viscomi, J. / Egli, D. / Bleu, M. / Katz, S. / Park, E. / Jang, D.M. / Porter, K.A. / Meili, F. / Guo, H. / Kerr, G. / Molle, S. / Velez-Vega, C. / Beyer, K.S. / Galli, G.G. / Maira, S.M. / Stams, T. / Clark, K. / Eck, M.J. / Tordella, L. / Thoma, C.R. / King, D.A.
External linksNature / PubMed:35830882
MethodsX-ray diffraction
Resolution1.9 - 1.95 Å
Structure data

PDB-7txh:
Human MRas Q71R in complex with human Shoc2 LRR domain M173I and human PP1Ca
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-7tyg:
Structure of the human leucine rich repeat protein SHOC2, residues 80-582
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-GNP:
PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER / GppNHp, GMPPNP, energy-carrying molecule analogue*YM

ChemComp-MG:
Unknown entry

ChemComp-GOL:
GLYCEROL

ChemComp-MN:
Unknown entry

ChemComp-PO4:
PHOSPHATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / RAS / PP1 / SHOC2 / LRR

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