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- PDB-7tvf: Crystal structure of the SHOC2-MRAS-PP1CA (SMP) complex to a reso... -
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Basic information
Entry | Database: PDB / ID: 7tvf | ||||||
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Title | Crystal structure of the SHOC2-MRAS-PP1CA (SMP) complex to a resolution of 2.17 Angstrom | ||||||
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![]() | SIGNALING PROTEIN / Oncoprotein Phosphatase Scaffold protein Adaptor RAS Leucine rich repeat | ||||||
Function / homology | ![]() cellular response to growth hormone stimulus / protein phosphatase type 1 complex / regulation of glycogen catabolic process / negative regulation of neural precursor cell proliferation / PTW/PP1 phosphatase complex / glycogen granule / regulation of glycogen biosynthetic process / GTP-dependent protein binding / cyclic-GMP-AMP transmembrane import across plasma membrane / nerve growth factor signaling pathway ...cellular response to growth hormone stimulus / protein phosphatase type 1 complex / regulation of glycogen catabolic process / negative regulation of neural precursor cell proliferation / PTW/PP1 phosphatase complex / glycogen granule / regulation of glycogen biosynthetic process / GTP-dependent protein binding / cyclic-GMP-AMP transmembrane import across plasma membrane / nerve growth factor signaling pathway / protein phosphatase regulator activity / protein phosphatase 1 binding / cadherin binding involved in cell-cell adhesion / SHOC2 M1731 mutant abolishes MRAS complex function / Gain-of-function MRAS complexes activate RAF signaling / positive regulation of extrinsic apoptotic signaling pathway in absence of ligand / positive regulation of Ras protein signal transduction / regulation of canonical Wnt signaling pathway / regulation of translational initiation / myosin phosphatase activity / branching morphogenesis of an epithelial tube / protein serine/threonine phosphatase activity / glycogen metabolic process / protein-serine/threonine phosphatase / Triglyceride catabolism / Maturation of hRSV A proteins / entrainment of circadian clock by photoperiod / phosphatase activity / phosphoprotein phosphatase activity / DARPP-32 events / negative regulation of neuron differentiation / fibroblast growth factor receptor signaling pathway / ribonucleoprotein complex binding / dephosphorylation / positive regulation of neuron differentiation / protein dephosphorylation / Downregulation of TGF-beta receptor signaling / small monomeric GTPase / G protein activity / cellular response to leukemia inhibitory factor / adherens junction / response to lead ion / RAF activation / lung development / circadian regulation of gene expression / regulation of circadian rhythm / positive regulation of neuron projection development / GDP binding / Circadian Clock / presynapse / actin cytoskeleton organization / perikaryon / protein phosphatase binding / Ras protein signal transduction / dendritic spine / cell cycle / cell division / GTPase activity / glutamatergic synapse / nucleolus / GTP binding / signal transduction / extracellular exosome / nucleoplasm / nucleus / metal ion binding / plasma membrane / cytoplasm / cytosol Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Bonsor, D.A. / Simanshu, D.K. | ||||||
Funding support | ![]()
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![]() | ![]() Title: Structure of the SHOC2-MRAS-PP1C complex provides insights into RAF activation and Noonan syndrome. Authors: Bonsor, D.A. / Alexander, P. / Snead, K. / Hartig, N. / Drew, M. / Messing, S. / Finci, L.I. / Nissley, D.V. / McCormick, F. / Esposito, D. / Rodriguez-Viciana, P. / Stephen, A.G. / Simanshu, D.K. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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PDBx/mmCIF format | ![]() | 844.6 KB | Display | ![]() |
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PDB format | ![]() | 688.7 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
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-Validation report
Summary document | ![]() | 1.1 MB | Display | ![]() |
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Full document | ![]() | 1.1 MB | Display | |
Data in XML | ![]() | 78.7 KB | Display | |
Data in CIF | ![]() | 111.8 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 7tvgC ![]() 1x1sS ![]() 6dnoS S: Starting model for refinement C: citing same article ( |
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Similar structure data | Similarity search - Function & homology ![]() |
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Assembly
Deposited unit | ![]()
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Noncrystallographic symmetry (NCS) | NCS domain:
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