Entry | Database: PDB / ID: 7ss1 |
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Title | The structure of NTMT1 in complex with compound GD433 |
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Components | N-terminal Xaa-Pro-Lys N-methyltransferase 1 |
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Keywords | TRANSFERASE/INHIBITOR / ntmt1 / methyltransferase / inhibitor / TRANSFERASE / TRANSFERASE-INHIBITOR complex |
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Function / homology | Function and homology information
N-terminal peptidyl-glycine methylation / N-terminal peptidyl-serine dimethylation / N-terminal peptidyl-serine trimethylation / protein N-terminal methyltransferase / N-terminal peptidyl-proline dimethylation / N-terminal protein N-methyltransferase activity / protein methyltransferase activity / spindle organization / histone methyltransferase activity / chromosome segregation ...N-terminal peptidyl-glycine methylation / N-terminal peptidyl-serine dimethylation / N-terminal peptidyl-serine trimethylation / protein N-terminal methyltransferase / N-terminal peptidyl-proline dimethylation / N-terminal protein N-methyltransferase activity / protein methyltransferase activity / spindle organization / histone methyltransferase activity / chromosome segregation / nucleoplasm / nucleus / cytoplasm / cytosolSimilarity search - Function Alpha-N-methyltransferase NTM1 / AdoMet dependent proline di-methyltransferase / S-adenosyl-L-methionine-dependent methyltransferase superfamilySimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.4 Å |
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Authors | Yadav, R. / Guangping, D. / Deng, Y. / Huang, R. / Noinaj, N. |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Cancer Institute (NIH/NCI) | | United States |
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Citation | Journal: To Be Published Title: Discovery of a first-in-class small molecule inhibitor for Protein N-terminal methyltransferases 1/2 Authors: Yadav, R. / Guangping, D. / Deng, Y. / Huang, R. / Noinaj, N. |
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History | Deposition | Nov 9, 2021 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Nov 16, 2022 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 18, 2023 | Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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