登録情報 データベース : PDB / ID : 7shi 構造の表示 ダウンロードとリンクタイトル Crystal Structure of Cytochrome P450 AmphL from Streptomyces nodosus and the Structural Basis for Substrate Selectivity in Macrolide Metabolizing P450s 要素AmphL 詳細 キーワード OXIDOREDUCTASE / amphotericin B / hydroxylase / p450 / cytochrome機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen / monooxygenase activity / iron ion binding / heme binding 類似検索 - 分子機能 Cytochrome P450, B-class / Cytochrome P450 / Cytochrome P450 superfamily / Cytochrome P450 類似検索 - ドメイン・相同性 Chem-4UH / PROTOPORPHYRIN IX CONTAINING FE / AmphL 類似検索 - 構成要素生物種 Streptomyces nodosus (バクテリア)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2 Å 詳細データ登録者 Amaya, J.A. / Poulos, T.L. 資金援助 米国, European Union, 2件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM131920 米国 European Regional Development Fund European Union
引用ジャーナル : J.Biol.Chem. / 年 : 2022タイトル : Structural analysis of P450 AmphL from Streptomyces nodosus provides insights into substrate selectivity of polyene macrolide antibiotic biosynthetic P450s.著者 : Amaya, J.A. / Lamb, D.C. / Kelly, S.L. / Caffrey, P. / Murarka, V.C. / Poulos, T.L. 履歴 登録 2021年10月8日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2022年3月9日 Provider : repository / タイプ : Initial release改定 1.1 2022年4月6日 Group : Database references / カテゴリ : citation / Item : _citation.journal_volume / _citation.title改定 1.2 2023年10月18日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model改定 2.0 2024年6月19日 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Database references / Derived calculations / Non-polymer description / Other / Polymer sequence / Refinement description / Source and taxonomy / Structure summary カテゴリ : atom_site / cell ... atom_site / cell / chem_comp / chem_comp_atom / chem_comp_bond / entity / entity_name_com / entity_poly / entity_poly_seq / entity_src_gen / pdbx_contact_author / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_poly_seq_scheme / pdbx_struct_conn_angle / pdbx_struct_sheet_hbond / pdbx_unobs_or_zero_occ_residues / pdbx_validate_close_contact / pdbx_validate_symm_contact / pdbx_validate_torsion / refine / refine_hist / refine_ls_restr / refine_ls_shell / software / struct_conf / struct_conn / struct_mon_prot_cis / struct_ref / struct_ref_seq / struct_sheet_range / symmetry Item : _cell.volume / _chem_comp.formula ... _cell.volume / _chem_comp.formula / _chem_comp.formula_weight / _chem_comp.name / _chem_comp.pdbx_synonyms / _entity.formula_weight / _entity.pdbx_description / _entity_name_com.name / _entity_poly.pdbx_seq_one_letter_code / _entity_poly.pdbx_seq_one_letter_code_can / _entity_src_gen.pdbx_end_seq_num / _pdbx_contact_author.id / _pdbx_entity_nonpoly.name / _pdbx_nonpoly_scheme.auth_seq_num / _pdbx_nonpoly_scheme.pdb_seq_num / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.value / _pdbx_struct_sheet_hbond.range_1_auth_comp_id / _pdbx_struct_sheet_hbond.range_1_auth_seq_id / _pdbx_struct_sheet_hbond.range_1_label_comp_id / _pdbx_struct_sheet_hbond.range_1_label_seq_id / _pdbx_struct_sheet_hbond.range_2_auth_comp_id / _pdbx_struct_sheet_hbond.range_2_auth_seq_id / _pdbx_struct_sheet_hbond.range_2_label_comp_id / _pdbx_struct_sheet_hbond.range_2_label_seq_id / _refine.B_iso_mean / _refine.ls_R_factor_R_free / _refine.ls_R_factor_R_work / _refine.ls_R_factor_obs / _refine.ls_d_res_high / _refine.ls_d_res_low / _refine.ls_number_reflns_R_work / _refine.ls_number_reflns_obs / _refine.ls_percent_reflns_R_free / _refine.ls_percent_reflns_obs / _refine.overall_SU_ML / _refine.pdbx_ls_sigma_F / _refine.pdbx_overall_phase_error / _refine.pdbx_stereochemistry_target_values / _refine_hist.d_res_high / _refine_hist.d_res_low / _refine_hist.pdbx_number_atoms_ligand / _refine_hist.pdbx_number_atoms_protein / _refine_ls_restr.dev_ideal / _refine_ls_restr.number / _refine_ls_restr.type / _refine_ls_shell.R_factor_R_free / _refine_ls_shell.R_factor_R_work / _refine_ls_shell.d_res_high / _refine_ls_shell.d_res_low / _refine_ls_shell.number_reflns_R_work / _refine_ls_shell.percent_reflns_obs / _software.version / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_seq_id / _struct_mon_prot_cis.label_seq_id / _struct_mon_prot_cis.pdbx_label_seq_id_2 / _struct_mon_prot_cis.pdbx_omega_angle / _struct_ref.pdbx_align_begin / _struct_ref.pdbx_seq_one_letter_code / _struct_ref_seq.db_align_beg / _struct_ref_seq.pdbx_auth_seq_align_beg / _struct_ref_seq.seq_align_end / _struct_sheet_range.beg_label_seq_id / _struct_sheet_range.end_label_seq_id / _symmetry.space_group_name_Hall 解説 : Model orientation/position詳細: 1. The previous ligand was missing 5 C=C (carbon carbon double bonds) and the chirality at C33 was S. Now added the missing double bonds and chirality at C33 was to R. 2. The orientation of ... 詳細 : 1. The previous ligand was missing 5 C=C (carbon carbon double bonds) and the chirality at C33 was S. Now added the missing double bonds and chirality at C33 was to R. 2. The orientation of mycosamine ring of the ligand was changed in the model. 3. Added one author to the list.Provider : author / タイプ : Coordinate replacement
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