Entry | Database: PDB / ID: 7shh |
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Title | Bacterial cereblon homologue in complex with (R)-3-(4-methoxyphenyl)piperidine-2,6-dione |
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Components | Cereblon isoform 4 |
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Keywords | SIGNALING PROTEIN / Cereblon / PROTAC / targeted protein degradation / TBD |
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Function / homology | CULT domain / CULT domain profile. / metal ion binding / (3R)-3-(4-methoxyphenyl)piperidine-2,6-dione / Cereblon isoform 4 Function and homology information |
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Biological species | Magnetospirillum gryphiswaldense (magnetotactic) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / FOURIER SYNTHESIS / Resolution: 1.9 Å |
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Authors | Nithianantham, S. / Fischer, M. |
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Funding support | 1items Organization | Grant number | Country |
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Other private | | |
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Citation | Journal: Acs Med.Chem.Lett. / Year: 2022 Title: Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs. Authors: Alcock, L.J. / Chang, Y. / Jarusiewicz, J.A. / Actis, M. / Nithianantham, S. / Mayasundari, A. / Min, J. / Maxwell, D. / Hunt, J. / Smart, B. / Yang, J.J. / Nishiguchi, G. / Fischer, M. / ...Authors: Alcock, L.J. / Chang, Y. / Jarusiewicz, J.A. / Actis, M. / Nithianantham, S. / Mayasundari, A. / Min, J. / Maxwell, D. / Hunt, J. / Smart, B. / Yang, J.J. / Nishiguchi, G. / Fischer, M. / Mullighan, C.G. / Rankovic, Z. |
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History | Deposition | Oct 8, 2021 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Apr 13, 2022 | Provider: repository / Type: Initial release |
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Revision 1.1 | May 22, 2024 | Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond / struct_ncs_dom_lim Item: _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id ..._struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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