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TitleDevelopment of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs.
Journal, issue, pagesAcs Med. Chem. Lett., Vol. 13, Page 475-482, Year 2022
Publish dateOct 8, 2021 (structure data deposition date)
AuthorsAlcock, L.J. / Chang, Y. / Jarusiewicz, J.A. / Actis, M. / Nithianantham, S. / Mayasundari, A. / Min, J. / Maxwell, D. / Hunt, J. / Smart, B. ...Alcock, L.J. / Chang, Y. / Jarusiewicz, J.A. / Actis, M. / Nithianantham, S. / Mayasundari, A. / Min, J. / Maxwell, D. / Hunt, J. / Smart, B. / Yang, J.J. / Nishiguchi, G. / Fischer, M. / Mullighan, C.G. / Rankovic, Z.
External linksAcs Med. Chem. Lett. / PubMed:35300081
MethodsX-ray diffraction
Resolution1.9 Å
Structure data

PDB-7shh:
Bacterial cereblon homologue in complex with (R)-3-(4-methoxyphenyl)piperidine-2,6-dione
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

Chemicals

ChemComp-ZN:
Unknown entry

ChemComp-9FT:
(3R)-3-(4-methoxyphenyl)piperidine-2,6-dione

ChemComp-HOH:
WATER

Source
  • magnetospirillum gryphiswaldense (magnetotactic)
KeywordsSIGNALING PROTEIN / Cereblon / PROTAC / targeted protein degradation / TBD

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