Entry | Database: PDB / ID: 7s5s |
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Title | CTX-M-15 WT in complex with BLIP WT |
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Components | - Beta-lactamase
- Beta-lactamase inhibitory protein
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Keywords | PROTEIN BINDING / Beta-lactamase / antibiotic resistance / Beta-lactamase inhibitory protein / protein complex |
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Function / homology | Function and homology information
regulation of beta-lactamase activity / beta-lactam antibiotic catabolic process / beta-lactamase activity / beta-lactamase / response to antibiotic / extracellular region / membraneSimilarity search - Function Beta-lactamase-inhibitor protein BLIP / Beta-lactamase-inhibitor protein BLIP domain superfamily / Beta-lactamase inhibitor (BLIP) / BamE-like / Beta-lactamase, class-A active site / Beta-lactamase class-A active site. / Beta-lactamase class A, catalytic domain / Beta-lactamase enzyme family / Beta-lactamase, class-A / Beta-lactamase/transpeptidase-likeSimilarity search - Domain/homology |
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Biological species | ![](img/tx_bacteria.gif) Escherichia coli (E. coli)
Streptomyces clavuligerus (bacteria) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.4 Å |
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Authors | Lu, S. / Palzkill, T. / Hu, L.Y. / Prasad, B.V.V. / Sankaran, B. |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Institute Of Allergy and Infectious Diseases (NIH/NIAID) | AI32956 | United States |
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Citation | Journal: Nat Commun / Year: 2022 Title: An active site loop toggles between conformations to control antibiotic hydrolysis and inhibition potency for CTX-M beta-lactamase drug-resistance enzymes. Authors: Lu, S. / Hu, L. / Lin, H. / Judge, A. / Rivera, P. / Palaniappan, M. / Sankaran, B. / Wang, J. / Prasad, B.V.V. / Palzkill, T. |
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History | Deposition | Sep 11, 2021 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Nov 30, 2022 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 25, 2023 | Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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