登録情報 データベース : PDB / ID : 7rjk 構造の表示 ダウンロードとリンクタイトル Crystal structure of human Bromodomain containing protein 3 (BRD3) in complex with hnRNPK 要素Bromodomain-containing protein 3 Heterogeneous nuclear ribonucleoprotein K 詳細キーワード SIGNALING PROTEIN / Brd3 / hnRNPK / acetyllysine機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / regulation of low-density lipoprotein particle clearance / regulation of mRNA splicing, via spliceosome / SUMOylation of RNA binding proteins / podosome / lncRNA binding / positive regulation of low-density lipoprotein receptor activity / endodermal cell differentiation / negative regulation of mRNA splicing, via spliceosome / Processing of Capped Intron-Containing Pre-mRNA ... regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / regulation of low-density lipoprotein particle clearance / regulation of mRNA splicing, via spliceosome / SUMOylation of RNA binding proteins / podosome / lncRNA binding / positive regulation of low-density lipoprotein receptor activity / endodermal cell differentiation / negative regulation of mRNA splicing, via spliceosome / Processing of Capped Intron-Containing Pre-mRNA / RNA processing / protein localization to chromatin / catalytic step 2 spliceosome / mRNA Splicing - Major Pathway / HCMV Late Events / molecular condensate scaffold activity / cell projection / lysine-acetylated histone binding / mRNA splicing, via spliceosome / cytoplasmic stress granule / positive regulation of receptor-mediated endocytosis / chromatin remodeling / ribonucleoprotein complex / cadherin binding / protein domain specific binding / focal adhesion / negative regulation of DNA-templated transcription / mRNA binding / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / signal transduction / positive regulation of transcription by RNA polymerase II / DNA binding / RNA binding / extracellular exosome / nucleoplasm / identical protein binding / membrane / nucleus / cytoplasm 類似検索 - 分子機能 ROK, N-terminal / ROKNT (NUC014) domain / KH domain / K Homology domain, type 1 / Type-1 KH domain profile. / K Homology domain, type 1 superfamily / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I ... ROK, N-terminal / ROKNT (NUC014) domain / KH domain / K Homology domain, type 1 / Type-1 KH domain profile. / K Homology domain, type 1 superfamily / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / K Homology domain / K homology RNA-binding domain / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily 類似検索 - ドメイン・相同性 Heterogeneous nuclear ribonucleoprotein K / Bromodomain-containing protein 3 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.85 Å 詳細データ登録者 Fedorov, E. / Islam, K. / Ghosh, A. 資金援助 米国, 3件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) R01GM123234 米国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) R01GM130752 米国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) P01GM118303 米国
引用ジャーナル : Biorxiv / 年 : 2021タイトル : Uncovering the Bromodomain Interactome using Site-Specific Azide-Acetyllysine Photochemistry, Proteomic Profiling and Structural Characterization著者 : Wagner, S. / Fedorov, E. / Sudhamalla, B. / Jnawali, H.N. / Debiec, R. / Ghosh, A. / Islam, K. 履歴 登録 2021年7月21日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2022年8月3日 Provider : repository / タイプ : Initial release改定 1.1 2022年8月24日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.pdbx_database_id_DOI / _citation.year / _citation_author.identifier_ORCID 改定 1.2 2023年10月18日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / pdbx_initial_refinement_model Item : _citation.journal_id_ISSN改定 1.3 2023年11月15日 Group : Data collection / カテゴリ : chem_comp_atom / chem_comp_bond / Item : _chem_comp_atom.atom_id / _chem_comp_bond.atom_id_2
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