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Yorodumi- PDB-7qs8: Structural insight into the Scribble PDZ domains interaction with... -
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-Basic information
Entry | Database: PDB / ID: 7qs8 | ||||||
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Title | Structural insight into the Scribble PDZ domains interaction with the oncogenic Human T-cell lymphotrophic virus-1 (HTLV-1) Tax1 | ||||||
Components |
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Keywords | VIRAL PROTEIN / Human T lymphotrophic virus-1 / HTLV-1 / cell polarity / isothermal titration calorimetry / Tax1 / PDZ / scribble | ||||||
Function / homology | Function and homology information symbiont-mediated perturbation of host exit from mitosis / : / neurotransmitter receptor transport postsynaptic membrane to endosome / symbiont-mediated perturbation of host cell cycle G0/G1 transition checkpoint / extrinsic component of postsynaptic density membrane / establishment of T cell polarity / apoptotic process involved in morphogenesis / establishment of apical/basal cell polarity / cochlear nucleus development / synaptic vesicle targeting ...symbiont-mediated perturbation of host exit from mitosis / : / neurotransmitter receptor transport postsynaptic membrane to endosome / symbiont-mediated perturbation of host cell cycle G0/G1 transition checkpoint / extrinsic component of postsynaptic density membrane / establishment of T cell polarity / apoptotic process involved in morphogenesis / establishment of apical/basal cell polarity / cochlear nucleus development / synaptic vesicle targeting / Scrib-APC-beta-catenin complex / astrocyte cell migration / polarized epithelial cell differentiation / myelin sheath abaxonal region / neurotransmitter receptor transport, endosome to postsynaptic membrane / protein localization to adherens junction / cell-cell contact zone / mammary gland duct morphogenesis / post-anal tail morphogenesis / establishment or maintenance of epithelial cell apical/basal polarity / activation of GTPase activity / regulation of postsynaptic neurotransmitter receptor internalization / auditory receptor cell stereocilium organization / RND2 GTPase cycle / RND3 GTPase cycle / positive regulation of receptor recycling / positive chemotaxis / receptor clustering / RHOJ GTPase cycle / RHOQ GTPase cycle / negative regulation of activated T cell proliferation / symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint / CDC42 GTPase cycle / synaptic vesicle endocytosis / negative regulation of mitotic cell cycle / immunological synapse / signaling adaptor activity / regulation of mRNA stability / Asymmetric localization of PCP proteins / neural tube closure / adherens junction / wound healing / cell-cell adhesion / SH3 domain binding / cell migration / cell-cell junction / positive regulation of type II interferon production / presynapse / cell junction / lamellipodium / basolateral plasma membrane / cellular response to lipopolysaccharide / cell population proliferation / host cell cytoplasm / postsynaptic density / cadherin binding / positive regulation of apoptotic process / negative regulation of gene expression / glutamatergic synapse / host cell nucleus / positive regulation of DNA-templated transcription / DNA binding / extracellular exosome / nucleoplasm / metal ion binding / plasma membrane Similarity search - Function | ||||||
Biological species | Homo sapiens (human) Human T-cell leukemia virus type I | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.85 Å | ||||||
Authors | Javorsky, A. / Soares da Costa, T.P. / Mackie, E.R. / Humbert, P.O. / Kvansakul, M. | ||||||
Funding support | 1items
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Citation | Journal: Febs J. / Year: 2023 Title: Structural insight into the Scribble PDZ domains interaction with the oncogenic Human T-cell lymphotrophic virus-1 (HTLV-1) Tax1 PBM. Authors: Javorsky, A. / Maddumage, J.C. / Mackie, E.R.R. / Soares da Costa, T.P. / Humbert, P.O. / Kvansakul, M. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 7qs8.cif.gz | 132.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb7qs8.ent.gz | 86.7 KB | Display | PDB format |
PDBx/mmJSON format | 7qs8.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/qs/7qs8 ftp://data.pdbj.org/pub/pdb/validation_reports/qs/7qs8 | HTTPS FTP |
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-Related structure data
Related structure data | 7qrsC 7qrtC 5vwiS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data | Similarity search - Function & homologyF&H Search |
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-Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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