登録情報 データベース : PDB / ID : 7qe8 構造の表示 ダウンロードとリンクタイトル Human cationic trypsin (TRY1) complexed with serine protease inhibitor Kazal type 1 (SPINK1) 要素Serine protease inhibitor Kazal-type 1 Trypsin-1 詳細キーワード HYDROLASE / TRY1 / SPINK1 / serine protease / protease-inhibitor complex / catalytic triad機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
negative regulation of nitric oxide mediated signal transduction / Uptake of dietary cobalamins into enterocytes / regulation of acrosome reaction / positive regulation of pancreatic juice secretion / regulation of store-operated calcium entry / negative regulation of peptidyl-tyrosine phosphorylation / negative regulation of calcium ion import / cellular response to peptide hormone stimulus / sperm capacitation / endopeptidase inhibitor activity ... negative regulation of nitric oxide mediated signal transduction / Uptake of dietary cobalamins into enterocytes / regulation of acrosome reaction / positive regulation of pancreatic juice secretion / regulation of store-operated calcium entry / negative regulation of peptidyl-tyrosine phosphorylation / negative regulation of calcium ion import / cellular response to peptide hormone stimulus / sperm capacitation / endopeptidase inhibitor activity / Activation of Matrix Metalloproteinases / positive regulation of peptide hormone secretion / extracellular matrix disassembly / trypsin / nitric oxide mediated signal transduction / digestion / response to nutrient levels / positive regulation of epithelial cell proliferation / serine-type endopeptidase inhibitor activity / positive regulation of cytosolic calcium ion concentration / collagen-containing extracellular matrix / response to ethanol / blood microparticle / serine-type endopeptidase activity / proteolysis / extracellular space / extracellular exosome / extracellular region / metal ion binding 類似検索 - 分子機能 Proteinase inhibitor I1, Kazal-type, metazoa / Kazal serine protease inhibitors family signature. / Kazal-type serine protease inhibitor domain / Kazal type serine protease inhibitors / Kazal domain superfamily / Kazal domain / Kazal domain profile. / : / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site ... Proteinase inhibitor I1, Kazal-type, metazoa / Kazal serine protease inhibitors family signature. / Kazal-type serine protease inhibitor domain / Kazal type serine protease inhibitors / Kazal domain superfamily / Kazal domain / Kazal domain profile. / : / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan 類似検索 - ドメイン・相同性 Serine protease inhibitor Kazal-type 1 / Serine protease 1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.9 Å 詳細データ登録者 Nagel, F. / Palm, G.J. / Delcea, M. / Lammers, M. 資金援助 European Union, 2件 詳細 詳細を隠す組織 認可番号 国 European Research Council (ERC) 637877 European Union European Union (EU) ESF/14-BM-A55-0047/16 European Union
引用ジャーナル : Int J Mol Sci / 年 : 2022タイトル : Structural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin.著者 : Nagel, F. / Palm, G.J. / Geist, N. / McDonnell, T.C.R. / Susemihl, A. / Girbardt, B. / Mayerle, J. / Lerch, M.M. / Lammers, M. / Delcea, M. 履歴 登録 2021年12月1日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2022年3月30日 Provider : repository / タイプ : Initial release改定 1.1 2022年4月27日 Group : Database references / カテゴリ : citation / Item : _citation.pdbx_database_id_PubMed / _citation.title改定 1.2 2024年5月1日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
すべて表示 表示を減らす