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TitleStructural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin.
Journal, issue, pagesInt J Mol Sci, Vol. 23, Year 2022
Publish dateDec 1, 2021 (structure data deposition date)
AuthorsNagel, F. / Palm, G.J. / Geist, N. / McDonnell, T.C.R. / Susemihl, A. / Girbardt, B. / Mayerle, J. / Lerch, M.M. / Lammers, M. / Delcea, M.
External linksInt J Mol Sci / PubMed:35408828
MethodsX-ray diffraction
Resolution2.1 - 2.9 Å
Structure data

PDB-7qe8:
Human cationic trypsin (TRY1) complexed with serine protease inhibitor Kazal type 1 (SPINK1)
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-7qe9:
Human cationic trypsin (TRY1) complexed with serine protease inhibitor Kazal type 1 N34S (SPINK1 N34S)
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE / TRY1 / SPINK1 / serine protease / protease-inhibitor complex / catalytic triad

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