Entry | Database: PDB / ID: 7q3p |
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Title | Crystal structure of IgG1-Fc-MST-HN (efgartigimod) |
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Components | IgG1-Fc-MST-HN |
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Keywords | IMMUNE SYSTEM / Fc / IgG1-Fc-MST-HN / efgartigimod / ARGX-113 / FcRn / FcRn-binding protein |
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Function / homology | beta-D-mannopyranose / alpha-L-fucopyranose / alpha-D-mannopyranose Function and homology information |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.1 Å |
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Authors | Pannecoucke, E. / Savvides, S.N. |
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Funding support | Belgium, 1items Organization | Grant number | Country |
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Research Foundation - Flanders (FWO) | | Belgium |
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Citation | Journal: Nat Commun / Year: 2022 Title: The Fab region of IgG impairs the internalization pathway of FcRn upon Fc engagement. Authors: Brinkhaus, M. / Pannecoucke, E. / van der Kooi, E.J. / Bentlage, A.E.H. / Derksen, N.I.L. / Andries, J. / Balbino, B. / Sips, M. / Ulrichts, P. / Verheesen, P. / de Haard, H. / Rispens, T. / ...Authors: Brinkhaus, M. / Pannecoucke, E. / van der Kooi, E.J. / Bentlage, A.E.H. / Derksen, N.I.L. / Andries, J. / Balbino, B. / Sips, M. / Ulrichts, P. / Verheesen, P. / de Haard, H. / Rispens, T. / Savvides, S.N. / Vidarsson, G. |
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History | Deposition | Oct 28, 2021 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Sep 28, 2022 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jan 25, 2023 | Group: Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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Revision 1.2 | Jan 31, 2024 | Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
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