- PDB-7q16: Human 14-3-3 zeta fused to the BAD peptide including phosphoserine-74 -
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Basic information
Entry
Database: PDB / ID: 7q16
Title
Human 14-3-3 zeta fused to the BAD peptide including phosphoserine-74
Components
14-3-3 protein zeta/delta,Bcl2-associated agonist of cell death
Keywords
SIGNALING PROTEIN / apoptotic regulation / phosphorylation / phosphopeptide binding
Function / homology
Function and homology information
ADP metabolic process / positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress / positive regulation of type B pancreatic cell development / positive regulation of glucokinase activity / BAD-BCL-2 complex / pore complex assembly / Golgi reassembly / synaptic target recognition / glucose catabolic process / respiratory system process ...ADP metabolic process / positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress / positive regulation of type B pancreatic cell development / positive regulation of glucokinase activity / BAD-BCL-2 complex / pore complex assembly / Golgi reassembly / synaptic target recognition / glucose catabolic process / respiratory system process / NOTCH4 Activation and Transmission of Signal to the Nucleus / regulation of synapse maturation / establishment of Golgi localization / type B pancreatic cell proliferation / BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members / tube formation / Rap1 signalling / activation of cysteine-type endopeptidase activity / cellular response to lipid / negative regulation of protein localization to nucleus / regulation of mitochondrial membrane permeability / positive regulation of mitochondrial membrane potential / AKT phosphorylates targets in the cytosol / positive regulation of T cell differentiation / KSRP (KHSRP) binds and destabilizes mRNA / positive regulation of B cell differentiation / GP1b-IX-V activation signalling / NRAGE signals death through JNK / Constitutive Signaling by AKT1 E17K in Cancer / positive regulation of insulin secretion involved in cellular response to glucose stimulus / cysteine-type endopeptidase activator activity involved in apoptotic process / positive regulation of release of cytochrome c from mitochondria / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / positive regulation of proteolysis / Regulation of localization of FOXO transcription factors / Interleukin-3, Interleukin-5 and GM-CSF signaling / extrinsic apoptotic signaling pathway via death domain receptors / phosphoserine residue binding / Activation of BAD and translocation to mitochondria / protein targeting / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / cellular response to glucose starvation / positive regulation of autophagy / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / extrinsic apoptotic signaling pathway / ATP metabolic process / RHO GTPases activate PKNs / extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of TORC1 signaling / protein sequestering activity / ERK1 and ERK2 cascade / negative regulation of innate immune response / hippocampal mossy fiber to CA3 synapse / intrinsic apoptotic signaling pathway / regulation of ERK1 and ERK2 cascade / release of cytochrome c from mitochondria / positive regulation of epithelial cell proliferation / Translocation of SLC2A4 (GLUT4) to the plasma membrane / Deactivation of the beta-catenin transactivating complex / TP53 Regulates Metabolic Genes / Negative regulation of NOTCH4 signaling / lung development / regulation of protein stability / positive regulation of insulin secretion / phospholipid binding / cytokine-mediated signaling pathway / cellular response to nicotine / cellular response to mechanical stimulus / activation of cysteine-type endopeptidase activity involved in apoptotic process / intrinsic apoptotic signaling pathway in response to DNA damage / melanosome / glucose homeostasis / cellular response to hypoxia / protein phosphatase binding / angiogenesis / DNA-binding transcription factor binding / vesicle / mitochondrial outer membrane / transmembrane transporter binding / blood microparticle / cadherin binding / positive regulation of apoptotic process / protein domain specific binding / protein phosphorylation / focal adhesion / glutamatergic synapse / lipid binding / apoptotic process / ubiquitin protein ligase binding / negative regulation of apoptotic process / protein kinase binding / negative regulation of transcription by RNA polymerase II / signal transduction / mitochondrion / RNA binding / extracellular space / extracellular exosome / nucleoplasm / identical protein binding Similarity search - Function
Bcl2-associated agonist of cell death / Pro-apoptotic Bcl-2 protein, BAD / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein Similarity search - Domain/homology
14-3-3proteinzeta/delta,Bcl2-associatedagonistofcelldeath / Protein kinase C inhibitor protein 1 / KCIP-1 / BAD / Bcl-2-binding component 6 / Bcl-2-like ...Protein kinase C inhibitor protein 1 / KCIP-1 / BAD / Bcl-2-binding component 6 / Bcl-2-like protein 8 / Bcl2-L-8 / Bcl-xL/Bcl-2-associated death promoter / Bcl2 antagonist of cell death
Mass: 27552.871 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: YWHAZ, BAD, BBC6, BCL2L8 / Production host: Escherichia coli (E. coli) / References: UniProt: P63104, UniProt: Q92934
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