- PDB-6zfd: 14-3-3 zeta bound to the phosphorylated 18E6 C-terminus -
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Basic information
Entry
Database: PDB / ID: 6zfd
Title
14-3-3 zeta bound to the phosphorylated 18E6 C-terminus
Components
14-3-3 protein zeta/delta,Protein E6
Keywords
PROTEIN BINDING / HPV / E6 oncoprotein / 14-3-3
Function / homology
Function and homology information
Golgi reassembly / synaptic target recognition / symbiont-mediated perturbation of host apoptosis / respiratory system process / NOTCH4 Activation and Transmission of Signal to the Nucleus / establishment of Golgi localization / regulation of synapse maturation / tube formation / Rap1 signalling / negative regulation of protein localization to nucleus ...Golgi reassembly / synaptic target recognition / symbiont-mediated perturbation of host apoptosis / respiratory system process / NOTCH4 Activation and Transmission of Signal to the Nucleus / establishment of Golgi localization / regulation of synapse maturation / tube formation / Rap1 signalling / negative regulation of protein localization to nucleus / KSRP (KHSRP) binds and destabilizes mRNA / GP1b-IX-V activation signalling / Regulation of localization of FOXO transcription factors / phosphoserine residue binding / Interleukin-3, Interleukin-5 and GM-CSF signaling / Activation of BAD and translocation to mitochondria / protein targeting / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / cellular response to glucose starvation / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / RHO GTPases activate PKNs / negative regulation of TORC1 signaling / protein sequestering activity / ERK1 and ERK2 cascade / negative regulation of innate immune response / hippocampal mossy fiber to CA3 synapse / regulation of ERK1 and ERK2 cascade / Translocation of SLC2A4 (GLUT4) to the plasma membrane / PDZ domain binding / Deactivation of the beta-catenin transactivating complex / TP53 Regulates Metabolic Genes / Negative regulation of NOTCH4 signaling / lung development / regulation of protein stability / protein localization / melanosome / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity / symbiont-mediated perturbation of host ubiquitin-like protein modification / angiogenesis / DNA-binding transcription factor binding / vesicle / transmembrane transporter binding / host cell cytoplasm / blood microparticle / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / cadherin binding / protein domain specific binding / protein phosphorylation / focal adhesion / virus-mediated perturbation of host defense response / negative regulation of DNA-templated transcription / DNA-templated transcription / glutamatergic synapse / ubiquitin protein ligase binding / host cell nucleus / negative regulation of apoptotic process / protein kinase binding / negative regulation of transcription by RNA polymerase II / signal transduction / DNA binding / RNA binding / extracellular space / extracellular exosome / zinc ion binding / nucleoplasm / identical protein binding / nucleus / cytosol / cytoplasm Similarity search - Function
E6 early regulatory protein / E6 superfamily / Early Protein (E6) / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein Similarity search - Domain/homology
14-3-3proteinzeta/delta,ProteinE6 / Protein kinase C inhibitor protein 1 / KCIP-1
Mass: 27394.764 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human), (gene. exp.) Human papillomavirus type 18 Gene: YWHAZ, E6 / Production host: Escherichia coli (E. coli) / References: UniProt: P63104, UniProt: P06463
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