登録情報 データベース : PDB / ID : 7prx 構造の表示 ダウンロードとリンクタイトル wildtype ligand binding domain of the glucocorticoid receptor complexed with velsecorat and a PGC1a coactivator fragment 要素Glucocorticoid receptor 糖質コルチコイド受容体 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha PPARγ 詳細キーワード SIGNALING PROTEIN / nuclear receptor (核内受容体) / ligand-activated transcription factor / agonist (アゴニスト)機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of mitochondrial DNA metabolic process / positive regulation of muscle tissue development / Regulation of NPAS4 gene transcription / regulation of glucocorticoid biosynthetic process / nuclear glucocorticoid receptor activity / positive regulation of cellular respiration / positive regulation of fatty acid oxidation / steroid hormone binding / PTK6 Expression / neuroinflammatory response ... positive regulation of mitochondrial DNA metabolic process / positive regulation of muscle tissue development / Regulation of NPAS4 gene transcription / regulation of glucocorticoid biosynthetic process / nuclear glucocorticoid receptor activity / positive regulation of cellular respiration / positive regulation of fatty acid oxidation / steroid hormone binding / PTK6 Expression / neuroinflammatory response / glucocorticoid metabolic process / : / microglia differentiation / mammary gland duct morphogenesis / maternal behavior / : / astrocyte differentiation / lncRNA binding / cellular response to glucocorticoid stimulus / response to muscle activity / 細胞呼吸 / Activation of PPARGC1A (PGC-1alpha) by phosphorylation / motor behavior / temperature homeostasis / regulation of gluconeogenesis / adrenal gland development / cellular response to steroid hormone stimulus / positive regulation of ATP biosynthetic process / response to starvation / intracellular glucose homeostasis / Β酸化 / response to dietary excess / estrogen response element binding / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / adipose tissue development / energy homeostasis / brown fat cell differentiation / intracellular steroid hormone receptor signaling pathway / core promoter sequence-specific DNA binding / positive regulation of gluconeogenesis / 消化 / cellular response to transforming growth factor beta stimulus / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / respiratory electron transport chain / TBP-class protein binding / steroid binding / mitochondrion organization / cellular response to dexamethasone stimulus / RNA splicing / SUMOylation of transcription cofactors / nuclear receptor coactivator activity / synaptic transmission, glutamatergic / chromosome segregation / 糖新生 / transcription initiation at RNA polymerase II promoter / nuclear receptor binding / negative regulation of smooth muscle cell proliferation / transcription coregulator activity / RNA polymerase II transcription regulatory region sequence-specific DNA binding / Hsp90 protein binding / circadian regulation of gene expression / Heme signaling / SUMOylation of intracellular receptors / Transcriptional activation of mitochondrial biogenesis / regulation of circadian rhythm / PPARA activates gene expression / chromatin DNA binding / PML body / 転写後修飾 / DNA-binding transcription repressor activity, RNA polymerase II-specific / positive regulation of DNA-binding transcription factor activity / positive regulation of miRNA transcription / Transcriptional regulation of white adipocyte differentiation / Nuclear Receptor transcription pathway / spindle / Regulation of RUNX2 expression and activity / nuclear receptor activity / positive regulation of neuron apoptotic process / sequence-specific double-stranded DNA binding / Circadian Clock / positive regulation of cold-induced thermogenesis / chromatin organization / cellular response to oxidative stress / 遺伝子発現 / DNA-binding transcription activator activity, RNA polymerase II-specific / protein-containing complex assembly / neuron apoptotic process / DNA-binding transcription factor binding / RNA polymerase II-specific DNA-binding transcription factor binding / negative regulation of neuron apoptotic process / Potential therapeutics for SARS / sequence-specific DNA binding / transcription coactivator activity / protein stabilization / DNA-binding transcription factor activity, RNA polymerase II-specific / ミトコンドリアマトリックス / nuclear speck / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / 細胞分裂 類似検索 - 分子機能 PGC-1alpha, RNA recognition motif / PGC-1 / 糖質コルチコイド受容体 / 糖質コルチコイド受容体 / RNA認識モチーフ / RNA認識モチーフ / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / 核内受容体 ... PGC-1alpha, RNA recognition motif / PGC-1 / 糖質コルチコイド受容体 / 糖質コルチコイド受容体 / RNA認識モチーフ / RNA認識モチーフ / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / 核内受容体 / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Nucleotide-binding alpha-beta plait domain superfamily 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.2 Å 詳細データ登録者 Edman, K. / Wissler, L. / Koehler, C. / Postel, S. 資金援助 1件 詳細 詳細を隠す 引用ジャーナル : Nat.Struct.Mol.Biol. / 年 : 2023タイトル : Quaternary glucocorticoid receptor structure highlights allosteric interdomain communication.著者: Postel, S. / Wissler, L. / Johansson, C.A. / Gunnarsson, A. / Gordon, E. / Collins, B. / Castaldo, M. / Kohler, C. / Oling, D. / Johansson, P. / Froderberg Roth, L. / Beinsteiner, B. / ... 著者 : Postel, S. / Wissler, L. / Johansson, C.A. / Gunnarsson, A. / Gordon, E. / Collins, B. / Castaldo, M. / Kohler, C. / Oling, D. / Johansson, P. / Froderberg Roth, L. / Beinsteiner, B. / Dainty, I. / Delaney, S. / Klaholz, B.P. / Billas, I.M.L. / Edman, K. 履歴 登録 2021年9月22日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2023年2月8日 Provider : repository / タイプ : Initial release改定 1.1 2023年2月15日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.pdbx_database_id_PubMed / _citation.title ... _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name 改定 1.2 2023年3月29日 Group : Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_last改定 1.3 2024年2月7日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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